[Ru(bpy)2(5-cyanouracil)2]2+ as a Potential Light-Activated Dual-Action Therapeutic Agent

The cation cis-[Ru(bpy)2(5CNU)2]2+ (bpy = 2,2′-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously r...

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Published in:Inorganic chemistry 2011-10, Vol.50 (19), p.9213-9215
Main Authors: Garner, Robert N, Gallucci, Judith C, Dunbar, Kim R, Turro, Claudia
Format: Article
Language:English
Subjects:
2,2'-Dipyridyl - chemistry
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
DNA - metabolism
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Dynamics Simulation
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Photolysis
Ruthenium - chemistry
Spectrophotometry, Ultraviolet
Uracil - analogs & derivatives
Uracil - chemistry
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cited_by cdi_FETCH-LOGICAL-a194u-9eed524a9b6f0eaa9f4c4617164aabcb5aa6e0e388b1160e9d83aa9382d7ce9b3
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container_issue 19
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container_title Inorganic chemistry
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creator Garner, Robert N
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description The cation cis-[Ru(bpy)2(5CNU)2]2+ (bpy = 2,2′-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating [Ru(bpy)2(H2O)2]2+. The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.
doi_str_mv 10.1021/ic201615u
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subjects 2,2'-Dipyridyl - chemistry
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
DNA - metabolism
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Dynamics Simulation
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Photolysis
Ruthenium - chemistry
Spectrophotometry, Ultraviolet
Uracil - analogs & derivatives
Uracil - chemistry
title [Ru(bpy)2(5-cyanouracil)2]2+ as a Potential Light-Activated Dual-Action Therapeutic Agent
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