[Ru(bpy)2(5-cyanouracil)2]2+ as a Potential Light-Activated Dual-Action Therapeutic Agent

The cation cis-[Ru(bpy)2(5CNU)2]2+ (bpy = 2,2′-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously r...

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Bibliographic Details
Published in:Inorganic chemistry 2011-10, Vol.50 (19), p.9213-9215
Main Authors: Garner, Robert N, Gallucci, Judith C, Dunbar, Kim R, Turro, Claudia
Format: Article
Language:English
Subjects:
2,2'-Dipyridyl - chemistry
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
DNA - metabolism
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Dynamics Simulation
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Photolysis
Ruthenium - chemistry
Spectrophotometry, Ultraviolet
Uracil - analogs & derivatives
Uracil - chemistry
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Summary:The cation cis-[Ru(bpy)2(5CNU)2]2+ (bpy = 2,2′-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating [Ru(bpy)2(H2O)2]2+. The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.
ISSN:0020-1669
1520-510X
DOI:10.1021/ic201615u