Long-term impact of chronic kidney disease in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial

This study sought to investigate the impact of chronic kidney disease (CKD) in patients undergoing percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) with different antithrombotic strategies. CKD is associated with increased risk of adverse ischemic and h...

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Bibliographic Details
Published in:JACC. Cardiovascular interventions 2011-09, Vol.4 (9), p.1011-1019
Main Authors: Saltzman, Adam J, Stone, Gregg W, Claessen, Bimmer E, Narula, Amar, Leon-Reyes, Selene, Weisz, Giora, Brodie, Bruce, Witzenbichler, Bernhard, Guagliumi, Giulio, Kornowski, Ran, Dudek, Dariusz, Metzger, D Christopher, Lansky, Alexandra J, Nikolsky, Eugenia, Dangas, George D, Mehran, Roxana
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Angioplasty, Balloon, Coronary - adverse effects
Angioplasty, Balloon, Coronary - instrumentation
Angioplasty, Balloon, Coronary - mortality
Anticoagulants - therapeutic use
Chi-Square Distribution
Chronic Disease
Drug-Eluting Stents
Europe
Female
Fibrinolytic Agents - therapeutic use
Hemorrhage
Heparin - therapeutic use
Hirudins
Humans
Israel
Kaplan-Meier Estimate
Kidney Diseases - complications
Kidney Diseases - mortality
Male
Metals
Middle Aged
Myocardial Infarction - complications
Myocardial Infarction - mortality
Myocardial Infarction - therapy
Peptide Fragments - therapeutic use
Platelet Aggregation Inhibitors - therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors
Proportional Hazards Models
Prospective Studies
Prosthesis Design
Recombinant Proteins - therapeutic use
Recurrence
Risk Assessment
Risk Factors
Stents
Stroke - etiology
Thrombosis - etiology
Time Factors
Treatment Outcome
United States
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Description
Summary:This study sought to investigate the impact of chronic kidney disease (CKD) in patients undergoing percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) with different antithrombotic strategies. CKD is associated with increased risk of adverse ischemic and hemorrhagic events after primary PCI for STEMI. HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial was a multicenter, international, randomized trial comparing bivalirudin monotherapy or heparin plus a glycoprotein IIb/IIIa inhibitor (GPI) during primary PCI in STEMI. CKD, defined as creatinine clearance
ISSN:1876-7605
DOI:10.1016/j.jcin.2011.06.012