Spatial frequency differentially affects habituation in migraineurs: a steady-state visual-evoked potential study

A lack of habituation in visual-evoked potentials (VEPs) is the main abnormality observed in migraineurs. However, no study of steady-state VEPs has yet evaluated pattern-reversal stimuli with respect to habituation behavior or spatial frequency. The aim of this study was to clarify habituation beha...

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Bibliographic Details
Published in:Documenta ophthalmologica 2011-10, Vol.123 (2), p.65-73
Main Authors: Shibata, Koichi, Yamane, Kiyomi, Nishimura, Yoshiko, Kondo, Hiromi, Otuka, Kuniaki
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Evoked Potentials, Visual - physiology
Female
Follow-Up Studies
Habituation, Psychophysiologic
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Migraine Disorders - physiopathology
Migraine Disorders - psychology
Neurology
Ophthalmology
Original Research Article
Pattern Recognition, Visual - physiology
Photic Stimulation
Reaction Time
Space Perception - physiology
Time Factors
Vascular diseases and vascular malformations of the nervous system
Young Adult
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Summary:A lack of habituation in visual-evoked potentials (VEPs) is the main abnormality observed in migraineurs. However, no study of steady-state VEPs has yet evaluated pattern-reversal stimuli with respect to habituation behavior or spatial frequency. The aim of this study was to clarify habituation behavior in migraineurs between attacks and to establish characteristics of VEPs in these patients. Steady-state VEPs were sequentially recorded as checkerboard patterns in four consecutive blocks from 12 patients with migraine without aura (MO), 12 patients with migraine with aura (MA), and 12 healthy controls (HC) at four spatial frequencies of 0.5, 1.0, 2.0, and 4.0 cycles per degree (cpd) with a stimulus rate of 7.5 Hz (15 reversal/s). VEP amplitudes were consistently higher in migraineurs. However, habituation was not demonstrated in HCs, and migraineurs did not reveal a clear lack of habituation. MAs exhibited high-amplitude VEPs, depending on spatial frequency. In the MA patients, amplitude differences reached statistical significance at 2.0 cpd. The sequential amplitude changes at 0.5 cpd were significantly different in MAs compared with HCs. Migraine patients exhibited high-amplitude VEPs, which were dependent on spatial frequency, and may be related to altered excitability in pre-cortical and cortical visual processing.
ISSN:0012-4486
1573-2622
DOI:10.1007/s10633-011-9281-2