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Natural products as catalysts for innovation: a pharmaceutical industry perspective
Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional...
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Published in: | Current opinion in chemical biology 2011-08, Vol.15 (4), p.497-504 |
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container_title | Current opinion in chemical biology |
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creator | Schmitt, Esther K Moore, Charles M Krastel, Philipp Petersen, Frank |
description | Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional sources through cultivation of microorganisms. Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies. However, to be of practical use for drug discovery, these concepts must be advanced beyond their current state. |
doi_str_mv | 10.1016/j.cbpa.2011.05.018 |
format | article |
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source | ScienceDirect Freedom Collection 2022-2024 |
subjects | Biodiversity Biological Products - chemistry Drug Discovery - methods Drug Industry - methods Epigenomics - methods Genome High-Throughput Screening Assays - methods Humans Molecular Probes - chemistry Molecular Structure Technology, Pharmaceutical - methods |
title | Natural products as catalysts for innovation: a pharmaceutical industry perspective |
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