Natural products as catalysts for innovation: a pharmaceutical industry perspective

Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional...

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Bibliographic Details
Published in:Current opinion in chemical biology 2011-08, Vol.15 (4), p.497-504
Main Authors: Schmitt, Esther K, Moore, Charles M, Krastel, Philipp, Petersen, Frank
Format: Article
Language:English
Subjects:
Biodiversity
Biological Products - chemistry
Drug Discovery - methods
Drug Industry - methods
Epigenomics - methods
Genome
High-Throughput Screening Assays - methods
Humans
Molecular Probes - chemistry
Molecular Structure
Technology, Pharmaceutical - methods
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Summary:Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional sources through cultivation of microorganisms. Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies. However, to be of practical use for drug discovery, these concepts must be advanced beyond their current state.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2011.05.018