Effects of Renal Sympathetic Denervation on Blood Pressure, Sleep Apnea Course, and Glycemic Control in Patients With Resistant Hypertension and Sleep Apnea

Percutaneous renal sympathetic denervation by radiofrequency energy has been reported to reduce blood pressure (BP) by the reduction of renal sympathetic efferent and afferent signaling. We evaluated the effects of this procedure on BP and sleep apnea severity in patients with resistant hypertension...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2011-10, Vol.58 (4), p.559-565
Main Authors: Witkowski, Adam, Prejbisz, Aleksander, Florczak, Elżbieta, Kądziela, Jacek, Śliwiński, Paweł, Bieleń, Przemysław, Michałowska, Ilona, Kabat, Marek, Warchoł, Ewa, Januszewicz, Magdalena, Narkiewicz, Krzysztof, Somers, Virend K, Sobotka, Paul A, Januszewicz, Andrzej
Format: Article
Language:English
Subjects:
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Glucose - metabolism
Blood Pressure - physiology
Cardiology. Vascular system
Catheter Ablation
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Comorbidity
Female
Follow-Up Studies
Glucose Intolerance - physiopathology
Humans
Hypertension - epidemiology
Hypertension - physiopathology
Hypertension - surgery
Kidney - innervation
Kidney - surgery
Male
Medical sciences
Middle Aged
Polysomnography
Severity of Illness Index
Sleep - physiology
Sleep Apnea, Obstructive - epidemiology
Sleep Apnea, Obstructive - physiopathology
Sleep Apnea, Obstructive - surgery
Sympathectomy - methods
Treatment Outcome
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Summary:Percutaneous renal sympathetic denervation by radiofrequency energy has been reported to reduce blood pressure (BP) by the reduction of renal sympathetic efferent and afferent signaling. We evaluated the effects of this procedure on BP and sleep apnea severity in patients with resistant hypertension and sleep apnea. We studied 10 patients with refractory hypertension and sleep apnea (7 men and 3 women; median age49.5 years) who underwent renal denervation and completed 3-month and 6-month follow-up evaluations, including polysomnography and selected blood chemistries, and BP measurements. Antihypertensive regimens were not changed during the 6 months of follow-up. Three and 6 months after the denervation, decreases in office systolic and diastolic BPs were observed (median−34/−13 mm Hg for systolic and diastolic BPs at 6 months; both P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.111.173799