Motor nerve biopsy: Clinical usefulness and histopathological criteria

Early differential diagnosis of motor neuropathies (MN) and lower motor neuron diseases (LMND) is important, as prognosis and therapeutic approaches are different. We evaluated the diagnostic contribution of the biopsy of the motor branch of the obturator nerve and gracilis muscle in 21 consecutive...

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Bibliographic Details
Published in:Annals of neurology 2011-01, Vol.69 (1), p.197-201
Main Authors: Riva, Nilo, Iannaccone, Sandro, Corbo, Massimo, Casellato, Chiara, Sferrazza, Barbara, Lazzerini, Alberto, Scarlato, Marina, Cerri, Federica, Previtali, Stefano C., Nobile-Orazio, Eduardo, Comi, Giancarlo, Quattrini, Angelo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy
Efferent Pathways - pathology
Humans
Injuries of the nervous system and the skull. Diseases due to physical agents
Medical sciences
Motor Neuron Disease - pathology
Muscle, Skeletal
Neurology
Neuromuscular Junction
Obturator Nerve
Peripheral Nervous System
Traumas. Diseases due to physical agents
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Summary:Early differential diagnosis of motor neuropathies (MN) and lower motor neuron diseases (LMND) is important, as prognosis and therapeutic approaches are different. We evaluated the diagnostic contribution of the biopsy of the motor branch of the obturator nerve and gracilis muscle in 21 consecutive patients in which, after proper clinical and neurophysiological studies, the differential diagnosis was still open. At baseline, motor biopsy was performed; diagnostic confirmation was obtained by 2‐year clinical follow‐up. Our results support the usefulness of this diagnostic procedure for selected cases of MN and LMND. Ann Neurol 2010
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.22110