Comparative inhibitory activity of the stilbenes resveratrol and oxyresveratrol on African swine fever virus replication

Stilbenols are polyphenolic phytoalexins produced by plants in response to biotic or abiotic stress. These compounds have received much attention because of their significant biological effects. One of these is their antiviral action, which has previously been documented for two members of this clas...

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Bibliographic Details
Published in:Antiviral research 2011-07, Vol.91 (1), p.57-63
Main Authors: Galindo, I., Hernáez, B., Berná, J., Fenoll, J., Cenis, J.L., Escribano, J.M., Alonso, C.
Format: Article
Language:English
Subjects:
African swine fever virus
African Swine Fever Virus - drug effects
African Swine Fever Virus - physiology
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antioxidants - pharmacology
Antiviral
Antiviral agents
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Line
Cercopithecus aethiops
DNA Replication - drug effects
Medical sciences
Oxyresveratrol
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - pharmacology
Polymerase Chain Reaction
Protein Synthesis Inhibitors - pharmacology
Resveratrol
Stilbenes - pharmacology
Virus Replication - drug effects
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Summary:Stilbenols are polyphenolic phytoalexins produced by plants in response to biotic or abiotic stress. These compounds have received much attention because of their significant biological effects. One of these is their antiviral action, which has previously been documented for two members of this class, namely resveratrol and oxyresveratrol. Here we tested the antiviral effect of these two compounds on African swine fever virus, the only member of the newly created family Asfarviridae and a serious limitation to porcine production worldwide. Our results show a potent, dose-dependent antiviral effect of resveratrol and oxyresveratrol in vitro. Interestingly, this antiviral activity was found for these synthetic compounds and also for oxyresveratrol extracted from new natural sources (mulberry twigs). The antiviral effect of these two drugs was demonstrated at concentrations that do not induce cytotoxicity in cultured cells. Moreover, these antivirals achieved a 98–100% reduction in viral titers. Both compounds allowed early protein synthesis but inhibited viral DNA replication, late viral protein synthesis and viral factory formation.
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2011.04.013