Towards the design of combination therapy for the treatment of enterovirus infections

We report here on a comparative study of the activity of 10 enterovirus inhibitors against poliovirus 1, enterovirus 71 and human rhinovirus 14. Three of the selected molecules (Pleconaril, BTA-798 and V-073) are in clinical development. The in vitro antiviral activity of pairwise combinations of in...

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Bibliographic Details
Published in:Antiviral research 2011-06, Vol.90 (3), p.213-217
Main Authors: Thibaut, Hendrik Jan, Leyssen, Pieter, Puerstinger, Gerhard, Muigg, Alexandra, Neyts, Johan, De Palma, Armando Mirko
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral
Antiviral agents
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Line
Combination therapy
Drug Interactions
Drug Therapy, Combination
Enterovirus
Enterovirus - drug effects
Enterovirus - physiology
Enterovirus Infections - drug therapy
Enterovirus Infections - virology
Human rhinovirus 14
Humans
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Poliovirus
Poliovirus 1
Rhinovirus
Virus
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Summary:We report here on a comparative study of the activity of 10 enterovirus inhibitors against poliovirus 1, enterovirus 71 and human rhinovirus 14. Three of the selected molecules (Pleconaril, BTA-798 and V-073) are in clinical development. The in vitro antiviral activity of pairwise combinations of inhibitors indicated that most combinations resulted in an additive to slightly synergistic antiviral activity. However, the combination of ribavirin with a nucleoside polymerase inhibitor resulted in a pronounced antagonistic effect.
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2011.03.187