Autoimmune neutropenia in children: analysis of 116 cases

To cite this article: Audrain M, Martin J, Fromont P, Prié N, Thomas C, Muller J‐Y. Autoimmune neutropenia in children: analysis of 116 cases. Pediatr Allergy Immunol 2011; 22: 494–496. Diagnosis of autoimmune neutropenia (AIN) in infants is important, because it allows the exclusion of more severe...

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Published in:Pediatric allergy and immunology 2011-08, Vol.22 (5), p.494-496
Main Authors: Audrain, Marie, Martin, Jérôme, Fromont, Patricia, Prié, Nolwen, Thomas, Caroline, Muller, et Jean-Yves
Format: Article
Language:English
Subjects:
Antibodies
Autoimmune Diseases - genetics
Autoimmune Diseases - immunology
autoimmunity
Biological and medical sciences
Child, Preschool
Children
Chronic infection
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gene Frequency
General aspects
Genotype
Hematologic and hematopoietic diseases
Humans
Hypersensitivity
Infant
Infants
Isoantibodies - blood
Isoantibodies - immunology
Isoantigens - genetics
Isoantigens - immunology
Leukemia
Leukocytes (neutrophilic)
Male
Medical sciences
Neutropenia
Neutropenia - genetics
Neutropenia - immunology
Neutrophils - immunology
Other diseases. Hematologic involvement in other diseases
Polymerase Chain Reaction - methods
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:To cite this article: Audrain M, Martin J, Fromont P, Prié N, Thomas C, Muller J‐Y. Autoimmune neutropenia in children: analysis of 116 cases. Pediatr Allergy Immunol 2011; 22: 494–496. Diagnosis of autoimmune neutropenia (AIN) in infants is important, because it allows the exclusion of more severe forms of neutropenia that have an increased risk for leukemia. AIN is characterized by chronic neutropenia, which spontaneously resolves within several months to a few years, and mild infections. Diagnosis is confirmed by the presence of antibodies directed against neutrophil antigens. The human neutrophil antigen (HNA) system is a polymorphic system, which includes five antigen groups with different polymorphisms. In AIN, antibodies are mostly directed against HNA‐1 (or against a specific allele of HNA‐1) and HNA‐4. Here, we present a series of 116 infants with AIN. We observed that anti‐neutrophil antibodies were present in 60% cases; directed against HNA‐1a in 73% of cases. In addition, we showed there was a bias in the HNA allele distribution in these infants because the frequency of the HNA‐1a allele was greater in comparison with controls.
ISSN:0905-6157
1399-3038
DOI:10.1111/j.1399-3038.2010.01117.x