importance of a judicious and early empiric choice of antimicrobial for methicillin-resistant Staphylococcus aureus bacteraemia

The purpose of this investigation was to examine the impact of antimicrobial regimens administered for hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia on the all-cause, 14-day mortality. We retrospectively examined the characteristics of the most effective empiric an...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2010-12, Vol.29 (12), p.1475-1479
Main Authors: Shime, N, Kosaka, T, Fujita, N
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antimicrobial agents
Area Under Curve
Bacteremia - drug therapy
Bacteremia - microbiology
Bacteremia - mortality
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blood - microbiology
Culture Media
Disease control
Drug Administration Schedule
Drug dosages
Female
Hospitals
Hospitals, University
Human bacterial diseases
Humans
Infectious diseases
Intensive care
Internal Medicine
Japan
Male
Medical Microbiology
Medical prognosis
Medical sciences
Medicine
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbial Sensitivity Tests
Middle Aged
Mortality
Patients
Pharmacokinetics
Retrospective Studies
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcal Infections - mortality
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus infections
Survival Rate
Time Factors
Treatment Outcome
Vancomycin - administration & dosage
Vancomycin - pharmacology
Vancomycin - therapeutic use
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Summary:The purpose of this investigation was to examine the impact of antimicrobial regimens administered for hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia on the all-cause, 14-day mortality. We retrospectively examined the characteristics of the most effective empiric antimicrobial therapy in 87 consecutive patients, hospitalised at a single institution between April 2003 and March 2008, who presented with clinically and microbiologically confirmed MRSA bacteraemia. The all-cause mortality was measured 14 days after the diagnosis was made. The administration of an effective antimicrobial against MRSA 400 μg h/ml (≥2.0 g/day). The empiric administration of antimicrobials effective against MRSA bacteraemia within 48 h after the collection of blood cultures increased the 14-day survival. If vancomycin is chosen, ≥2.0 g/day should be administered, starting within 48 h.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-010-1024-x