A cohort study to evaluate the effectiveness of laparoscopic-guided local injection of etoposide in the management of women with unruptured tubal pregnancy

Objective To assess the feasibility of laparoscopic-guided local injection of etoposide or methotrexate (MTX) in the management of unruptured tubal pregnancy and compare the effectiveness of the two regimens. Design Retrospective cohort study. Setting Medical center. Patient(s) Thirty-one women with...

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Bibliographic Details
Published in:Fertility and sterility 2011-09, Vol.96 (3), p.654-658
Main Authors: Chen, Ching-Hui, M.D, Lee, Wen-Ling, M.D., Ph.D, Chiu, Li-Hsuan, Ph.D, Sun, Hsu-Dong, M.D, Liu, Wei-Min, M.D, Wang, Peng-Hui, M.D., Ph.D
Format: Article
Language:English
Subjects:
Abortifacient Agents, Nonsteroidal - administration & dosage
Adult
Antineoplastic Agents, Phytogenic - administration & dosage
Biological and medical sciences
blood serum
Cohort Studies
conservative treatment
Digestive system. Abdomen
Diseases of mother, fetus and pregnancy
Endoscopy
etoposide
Etoposide - administration & dosage
Fallopian Tubes - pathology
Female
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Injections - methods
Internal Medicine
Investigative techniques, diagnostic techniques (general aspects)
laparoscopic-guided local injection
Laparoscopy - methods
Medical sciences
methotrexate
Methotrexate - administration & dosage
Obstetrics and Gynecology
patients
Pregnancy
Pregnancy, Tubal - drug therapy
Pregnancy, Tubal - pathology
Pregnancy. Fetus. Placenta
Retrospective Studies
Treatment Outcome
women
β-human chorionic gonadotropin
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Summary:Objective To assess the feasibility of laparoscopic-guided local injection of etoposide or methotrexate (MTX) in the management of unruptured tubal pregnancy and compare the effectiveness of the two regimens. Design Retrospective cohort study. Setting Medical center. Patient(s) Thirty-one women with laparoscopically diagnosed unruptured tubal pregnancy. Intervention(s) A regimen of etoposide 50 mg via laparoscopic-guided local injection (n = 17) compared with a conventional MTX 50 mg regimen (n = 11), after 3 patients were excluded (2 refusals and 1 with salpingostomy). Main Outcome Measure(s) Serial serum β-hCG levels and the success rate in both groups. Result(s) General characteristics of the patients were similar in both groups. The overall success rate was 96.4% (27 of 28). The duration between treatment and nadir of serum β-hCG level (
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2011.06.033