Alterations in Downstream Mediators Involved in Central Control of Eating Behavior in Obese Adolescents Submitted to a Multidisciplinary Therapy

Abstract Objective The aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein [AgRP], neuropeptide Y [NPY], and melanin-concentrating hormone) and anorexigenic fa...

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Published in:Journal of adolescent health 2011-09, Vol.49 (3), p.300-305
Main Authors: Prado, Wagner L., Ph.D, Oyama, Lila M., Ph.D, Lofrano-Prado, Mara C., M.S, de Piano, Aline, M.S, Stella, Sérgio G., Ph.D, Nascimento, Cláudia M.O., Ph.D, Carnier, June, M.S, Caranti, Danielle A., Ph.D, Tock, Lian, M.D, Tufik, Sérgio, Ph.D, de Mello, Marco Túlio, Ph.D, Dâmaso, Ana R., Ph.D
Format: Article
Language:English
Subjects:
Adolescent
Adolescent Health Services
Adolescents
Agouti-Related Protein - blood
alpha-MSH - blood
Biological and medical sciences
Body Weight
Combined Modality Therapy
Diet, Reducing - methods
Exercise
Feeding Behavior
Female
Food
Food intake
Ghrelin
Ghrelin - blood
Hormone replacement therapy
Hormones
Humans
Hypothalamic Hormones - blood
Insulin
Leptin
Leptin - blood
Male
Medical sciences
Melanins - blood
Metabolic diseases
Neuropeptide Y - blood
Neuropeptides
Obesity
Obesity - blood
Obesity - metabolism
Obesity - therapy
Pediatrics
Peptide Hormones - blood
Pituitary Hormones - blood
Weight Loss
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Summary:Abstract Objective The aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein [AgRP], neuropeptide Y [NPY], and melanin-concentrating hormone) and anorexigenic factors (leptin, insulin, and alpha-melanocyte stimulating hormone [α-MSH]), in obese adolescents. Methods A total of 88 adolescents (38 boys and 50 girls), including 62 obese and 26 normal-weight, aged 15–19 years were recruited. Obese adolescents were submitted to a 24-week multidisciplinary therapy. AgRP, NPY, melanin-concentrating hormone, leptin, insulin, glucose, α-MSH, total ghrelin, and food intake were measured at three stages (at baseline, after 12 weeks, and after 24 weeks). Results At baseline, obese adolescents showed hyperleptinemia (circulating leptin levels, which were, in boys and girls, 40 and 35 times higher than in normal-weight subjects, respectively). After 24 weeks, these values decreased in all obese patients. Our results showed no differences in ghrelin levels between obese and normal-weight adolescents, in both genders. However, obese boys reduced their plasma ghrelin concentration after 24 weeks of therapy ( p < .05). The multidisciplinary therapy decreased NPY and AgRP values and increased α-MSH; simultaneously with these changes there was a decrease in total food intake after 24 weeks of therapy. Conclusions We can conclude that the multidisciplinary therapy was efficient to modulate neurohormonal control of food intake in obese adolescents.
ISSN:1054-139X
1879-1972
DOI:10.1016/j.jadohealth.2010.12.016