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Placental expression of a novel primate‐specific splice variant of sFlt‐1 is upregulated in pregnancies complicated by severe early onset pre‐eclampsia
Please cite this paper as: Whitehead C, Palmer K, Nilsson U, Gao Y, Saglam B, Lappas M, Tong S. Placental expression of a novel primate‐specific splice variant of sFlt‐1 is upregulated in pregnancies complicated by severe early onset pre‐eclampsia. BJOG 2011; DOI: 10.1111/j.1471‐0528.2011.02962.x. s...
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Published in: | BJOG : an international journal of obstetrics and gynaecology 2011-09, Vol.118 (10), p.1268-1271 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Please cite this paper as: Whitehead C, Palmer K, Nilsson U, Gao Y, Saglam B, Lappas M, Tong S. Placental expression of a novel primate‐specific splice variant of sFlt‐1 is upregulated in pregnancies complicated by severe early onset pre‐eclampsia. BJOG 2011; DOI: 10.1111/j.1471‐0528.2011.02962.x.
sFlt‐1 is increased in the placenta and serum of women with pre‐eclampsia. A novel primate‐specific splice variant has recently been discovered, but its expression in severe pre‐eclampsia has yet to be reported. We investigated placental expression of the previously described variant, sFlt‐1/sFlt‐i13, and the novel variant, sFlt‐e15a, in pregnancies complicated by severe early onset pre‐eclampsia (n = 14) and HELLP (haemolysis, elevated liver enzymes and a low platelet count) syndrome (n = 8). There was significant upregulation of both variants in pre‐eclampsia and HELLP syndrome compared with normotensive term (n = 35) and preterm controls (n = 8). We conclude that the novel primate‐specific splice variant of sFlt‐1 is highly expressed in both severe pre‐eclampsia and HELLP. |
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ISSN: | 1470-0328 1471-0528 |
DOI: | 10.1111/j.1471-0528.2011.02962.x |