The role of fibroblast growth factor-2 in healing the dura mater after inducing cerebrospinal fluid leakage in rats

Abstract We conducted a study to determine the effectiveness of topically applied recombinant mouse fibroblast growth factor-2 (FGF-2) in healing the dura mater in a rat with dura mater injury and cerebrospinal fluid leakage. Laminectomies were performed in 32 rats at the level of the L2–L4 vertebra...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2009-04, Vol.16 (4), p.542-544
Main Authors: Nurata, Hakan, Cemil, Berker, Kurt, Gökhan, Uçankuş, Neşe Lortlar, Dogulu, Fikret, Ömeroğlu, Suna
Format: Article
Language:English
Subjects:
Animals
Cerebrospinal fluid leakage
Chi-Square Distribution
Disease Models, Animal
Dura mater
Dura Mater - drug effects
Dura Mater - injuries
Fibroblast Growth Factor 2 - therapeutic use
Fibroblast growth factor-2
Fibroblasts - drug effects
Male
Neurology
Rat
Rats
Rats, Wistar
Subdural Effusion - pathology
Subdural Effusion - therapy
Time Factors
Wound Healing - drug effects
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Summary:Abstract We conducted a study to determine the effectiveness of topically applied recombinant mouse fibroblast growth factor-2 (FGF-2) in healing the dura mater in a rat with dura mater injury and cerebrospinal fluid leakage. Laminectomies were performed in 32 rats at the level of the L2–L4 vertebrae, and a dura mater defect was created. Sixteen rats were treated postoperatively with locally applied recombinant mouse FGF-2, and 16 animals received normal saline. FGF-2 effects on dura mater healing, cerebrospinal fluid leakage, and wound healing were assessed at 3 and 6 weeks postoperatively. The extent of dura mater healing was evaluated by histological analysis. We found that dura mater healing was significantly increased ( p < 0.05) in rats treated with FGF-2 compared with rats in the control group. In this experimental model, locally applied FGF-2 effectively increased dura mater healing and induced no side effects.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2008.05.021