Carotid intima-media thickness and cerebrovascular reactivity in long-term type 1 diabetes mellitus

Purpose Diabetes mellitus (DM) is one of the leading risk factors for cerebrovascular diseases. Both macro‐ and microvascular damage may occur. The aim of the present work was to assess intima‐media thickness as well as cerebral vasoreactivity in patients suffering from type 1 diabetes mellitus (IDD...

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Published in:Journal of clinical ultrasound 2009-10, Vol.37 (8), p.451-456
Main Authors: Siró, Péter, Molnár, Csilla, Katona, Éva, Antek, Csaba, Kollár, József, Settakis, Georgios, Fülesdi, Béla
Format: Article
Language:English
Subjects:
Adult
and microangiopathy
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Cerebral blood flow
cerebral macro
cerebral vasoreactivity
Cerebrovascular Circulation - physiology
Cerebrovascular diseases
Diabetes mellitus
Diabetes Mellitus, Type 1 - diagnostic imaging
Diabetes Mellitus, Type 1 - physiopathology
Disease Progression
Female
Follow-Up Studies
Humans
Hyperventilation
IDDM
intima-media thickness
Male
Microvasculature
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - physiopathology
Nephropathy
Retinopathy
Risk factors
Severity of Illness Index
Time Factors
transcranial Doppler
Tunica Intima - diagnostic imaging
Ultrasonography, Doppler, Transcranial - methods
Ultrasound
Vasoconstrictors
Vasodilation - physiology
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Summary:Purpose Diabetes mellitus (DM) is one of the leading risk factors for cerebrovascular diseases. Both macro‐ and microvascular damage may occur. The aim of the present work was to assess intima‐media thickness as well as cerebral vasoreactivity in patients suffering from type 1 diabetes mellitus (IDDM). Methods Intima‐media thickness and resting middle cerebral artery blood flow velocity was measured in 33 IDDM patients and 31 healthy controls. After baseline investigations, 30 seconds of breath holding (BH) and 60 seconds of voluntary hyperventilation (HV) were performed by the subjects. Transcranial Doppler measurements were performed in each case after vasodilatory (BH) and vasoconstrictor (HV) stimuli. Cerebrovascular reactivity was expressed as the percentage of change of the middle cerebral mean blood flow velocity after BH or HV. Results IDDM patients showed a significantly larger intima‐media thickness (0.1 ± 0.02 mm) than healthy controls (0.06 ± 0.006 mm, p < 0.001). Cerebrovascular reactivity after BH was less intensive in diabetic patients (19.3 ± 16.1%) than that of the control subjects (38.7 ± 22.8%, p < 0.01). Similarly, HV induced a less‐pronounced decrease of cerebral blood flow velocity in diabetic subjects (–30.1 ± 13.2%) than in nondiabetics (–37.6 ± 17.0%, p < 0.05). Conclusion Our results refer to early macro‐ and microangiopathic involvement of the cerebral vessels, which develop in parallel with angiopathies of the other organs, such as nephropathy and retinopathy. Further prospective studies are needed to clarify the role of these macro‐ and microangiopathic changes in the development of cerebrovascular complications in patients suffering from DM. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2009
ISSN:0091-2751
1097-0096
1097-0096
DOI:10.1002/jcu.20617