Bioceramic inlays do not improve mechanical incorporation of grit-blasted titanium stems in the proximal sheep femur

The aim of the present study was to determine, if bioactive glass (BG) surface inlays improve osseointegration of titanium implants in the proximal femur of adult sheep. In simulation of uncemented primary stems (nine animals), only the proximal part of the implants was grit‐blasted and three surfac...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2010-03, Vol.92A (4), p.1578-1586
Main Authors: Keränen, Pauli, Koort, Jyri, Itälä, Ari, Ylänen, Heimo, Dalstra, Michel, Hupa, Mikko, Kommonen, Bertel, Aro, Hannu T.
Format: Article
Language:English
Subjects:
Animals
bioactive glass
Biocompatible Materials - chemistry
Biological and medical sciences
bone graft substitute
Female
femur
Femur - anatomy & histology
Femur - diagnostic imaging
Femur - metabolism
Femur - surgery
Glass - chemistry
Implants, Experimental
Materials Testing
Medical sciences
Microspheres
Orthopedic surgery
Radiography
Sheep
Stress, Mechanical
Surface Properties
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Titanium - chemistry
titanium implant
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the present study was to determine, if bioactive glass (BG) surface inlays improve osseointegration of titanium implants in the proximal femur of adult sheep. In simulation of uncemented primary stems (nine animals), only the proximal part of the implants was grit‐blasted and three surface slots of the grit‐blasted region were filled with sintered BG microspheres. Primary stems were implanted using press‐fit technique. In revision stem simulation (eight animals), grit‐blasting was extended over the whole implant and seven perforating holes of the stem were filled by sintered BG granules. Revision stems were implanted with a mixture of autogenous bone graft and BG granules. Comparison with solid partially or fully grit‐blasted control stems implanted in the contralateral femurs was performed in the primary and revision stem experiments at 12 and 25 weeks, respectively. Implant incorporation was evaluated by torsional failure testing and histomorphometry. Only one‐third of the primary stems anchored mechanically to bone. The revision stems incorporated better and the BG inlays of the revision stems showed ingrowth of new bone. However, there were no significant differences in the torsional failure loads between the stems with BG inlays and the control stems. In conclusion, surface BG inlays gave no measurable advantage in mechanical incorporation of grit‐blasted titanium implants. Overall, the proximal sheep femur, characterized by minimal amount of cancellous bone and the presence of adipocytic bone marrow, seemed to present compromised bone healing conditions. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
ISSN:1549-3296
1552-4965
1552-4965
DOI:10.1002/jbm.a.32494