ULBP4/RAET1E is highly polymorphic in the Old World monkey

Natural-killer group 2 member D (NKG2D) is an activating receptor that plays an important role in the immune response mediated by NK cells, γδ + T cells, and CD8 + T cells. In humans, MHC class I chain-related genes and UL-16 binding protein (ULBP)/retinoic acid early transcript 1 (REAT1) gene famil...

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Bibliographic Details
Published in:Immunogenetics (New York) 2011-08, Vol.63 (8), p.501-509
Main Authors: Naruse, Taeko K., Okuda, Yukiko, Mori, Kazuyasu, Akari, Hirofumi, Matano, Tetsuro, Kimura, Akinori
Format: Article
Language:English
Subjects:
Allergology
Amino Acid Sequence
Animals
Biomedical and Life Sciences
Biomedicine
Carrier Proteins - chemistry
Carrier Proteins - genetics
Cell Biology
Chromosomes
Cloning
Gene Function
Genes
Genetic diversity
Genomes
Histocompatibility Antigens Class I - chemistry
Histocompatibility Antigens Class I - genetics
Human Genetics
Humans
Immunology
Infectious diseases
Laboratory animals
Ligands
Lymphocytes
Macaca
Macaca fascicularis - genetics
Macaca mulatta - genetics
Membrane Proteins - chemistry
Membrane Proteins - genetics
Molecular Sequence Data
Monkeys & apes
Original Paper
Pathogens
Phylogeny
Polymorphism, Genetic
Primates
Proteins
Sequence Alignment
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Summary:Natural-killer group 2 member D (NKG2D) is an activating receptor that plays an important role in the immune response mediated by NK cells, γδ + T cells, and CD8 + T cells. In humans, MHC class I chain-related genes and UL-16 binding protein (ULBP)/retinoic acid early transcript 1 (REAT1) gene family encode ligands for NKG2D. The rhesus and crab-eating macaques, which belong to the Old World monkeys, are widely used as non-human primate models in medical researches on the immunological process. In the present study, we investigated the polymorphisms of ULBP4 / RAET1E , a member of the ULBP/RAET1 family, and found 25 and 14 alleles from the rhesus and crab-eating macaques, respectively, of which diversities were far more extended than in humans. A phylogenetic study suggested that the allelic diversification of ULBP4/RAET1E predated the divergence of rhesus and crab-eating macaques.
ISSN:0093-7711
1432-1211
DOI:10.1007/s00251-011-0531-y