Effects of intravitreal bevacizumab (Avastin®) therapy on retrobulbar blood flow parameters in patients with neovascular age-related macular degeneration

Background. To investigate the effects of intravitreal bevacizumab on retrobulbar circulation in patients with neovascular age‐related macular degeneration (AMD). Method. Thirty patients with neovascular age‐related macular degeneration were assessed prospectively by both color Doppler imaging and f...

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Bibliographic Details
Published in:Journal of clinical ultrasound 2010-02, Vol.38 (2), p.66-70
Main Authors: Mete, Ahmet, Saygılı, Oguzhan, Mete, Alper, Bayram, Metin, Bekır, Necdet
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Angiogenesis Inhibitors - administration & dosage
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal, Humanized
Bevacizumab
Blood Flow Velocity - drug effects
Blood Flow Velocity - physiology
color Doppler imaging
Female
Follow-Up Studies
Humans
Injections
intravitreal bevacizumab injection
Macular Degeneration - complications
Macular Degeneration - diagnosis
Macular Degeneration - drug therapy
Male
Middle Aged
neovascular age-related macular degeneration
Ophthalmic Artery - diagnostic imaging
Ophthalmic Artery - physiopathology
Prospective Studies
Regional Blood Flow - drug effects
Regional Blood Flow - physiology
Retinal Artery - diagnostic imaging
Retinal Artery - physiopathology
Retinal Neovascularization - diagnosis
Retinal Neovascularization - drug therapy
Retinal Neovascularization - etiology
Retinal Vein - diagnostic imaging
Retinal Vein - physiopathology
retrobulbar blood flow
Treatment Outcome
Ultrasonography, Doppler, Color - methods
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Vitreous Body
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Summary:Background. To investigate the effects of intravitreal bevacizumab on retrobulbar circulation in patients with neovascular age‐related macular degeneration (AMD). Method. Thirty patients with neovascular age‐related macular degeneration were assessed prospectively by both color Doppler imaging and fundus fluorescein angiography. Spectral Doppler analysis allowed the measurement of the maximum velocity (Vmax) and minimum velocity (Vmin) of the central retinal vein (CRV), and peak systolic (PSV), end‐diastolic (EDV) velocities of blood flows, and pulsatility index (PI) and resistance index (RI) values in the central retinal artery (CRA), nasal and temporal posterior ciliary arteries (NPCA, TPCA), and ophthalmic artery (OA). The t test for paired samples was used to compare retrobulbar blood flow values before and after intravitreal bevacizumab injection. Result. PSV and EDV of the NPCA and PSV of the TPCA were significantly decreased after intravitreal bevacizumab injection (p < 0.05). There was no statistically significant difference in the other parameters. Conclusion. Our results suggest that intravitreal bevacizumab therapy has a measurable effect on retrobulbar blood flow. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound 2010
ISSN:0091-2751
1097-0096
1097-0096
DOI:10.1002/jcu.20650