A newborn with Pierre Robin sequence after preconceptional mitoxantrone exposure of a female with multiple sclerosis

Abstract Multiple sclerosis is a common disease of young adults in which accidental and unplanned pregnancies under disease modifying or immunosuppressive therapies may occur. The experience with mitoxantrone (MIX) especially in the first trimenon is very limited, until now only one case of a pregna...

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Bibliographic Details
Published in:Journal of the neurological sciences 2011-08, Vol.307 (1), p.164-165
Main Authors: Hellwig, Kerstin, Schimrigk, Sebastian, Chan, Andrew, Epplen, Jörg, Gold, Ralf
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - metabolism
Abnormalities, Drug-Induced - pathology
Adult
Antiemetics - therapeutic use
Antineoplastic Agents - adverse effects
Biological and medical sciences
Female
Humans
Infant, Newborn
Male
Medical sciences
Mitoxantrone - adverse effects
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Multiple Sclerosis, Chronic Progressive - drug therapy
Multiple Sclerosis, Chronic Progressive - metabolism
Neurology
Ondansetron - therapeutic use
Orofacial cleft
Pierre Robin sequence
Pierre Robin Syndrome - chemically induced
Pierre Robin Syndrome - metabolism
Pierre Robin Syndrome - pathology
Preconception Injuries
Pregnancy
Pregnancy, Unplanned - drug effects
Prenatal Exposure Delayed Effects - chemically induced
Prenatal Exposure Delayed Effects - metabolism
Prenatal Exposure Delayed Effects - pathology
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Summary:Abstract Multiple sclerosis is a common disease of young adults in which accidental and unplanned pregnancies under disease modifying or immunosuppressive therapies may occur. The experience with mitoxantrone (MIX) especially in the first trimenon is very limited, until now only one case of a pregnant woman with MS who was exposed to MIX in early pregnancy and delivered a growth restricted but healthy child was published. We report a case of a secondary progressive MS patient who was exposed periconceptionally to MIX and delivered a child with Pierre Robin Sequence (PRS), a syndrome with the main features of glossoptosis, micrognathia, and palate clefts. PRS is a very rare defect and therefore a causal relation with MIX seems possible.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2011.05.003