Bone bioelectricity: What have we learned in the past 160 years?

The direct relationship between bone strain and electric fields has spurred continual interest in the field of bioelectricity over the past 160 years. It has been reported that stress‐generated potentials alter cell proliferation and extracellular matrix secretion. The observation that endogenous el...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2010-12, Vol.95A (4), p.1270-1279
Main Authors: Isaacson, Brad M., Bloebaum, Roy D.
Format: Article
Language:English
Subjects:
Animals
bioelectricity
Biological and medical sciences
bone
Bone and Bones - physiology
Electric Stimulation Therapy
electrical stimulation
Electricity - history
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Medical sciences
Orthopedics
Osseointegration
piezoelectricity
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
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Summary:The direct relationship between bone strain and electric fields has spurred continual interest in the field of bioelectricity over the past 160 years. It has been reported that stress‐generated potentials alter cell proliferation and extracellular matrix secretion. The observation that endogenous electrical signals facilitate osteoinduction has lead to high production of electrical stimulation devices to fix bone defects. Despite the reported 100,000 nonunions healed as of 1990 with electrical stimulation, skepticism due to lack of homogeneity with trial design and dosage still exists within the scientific community. It is the purpose of this review to assess the bioelectric phenomenon of bone as it applies to piezoelectricity, fracture healing, and overall changes in bone metabolism which occur with controlled electrical stimulation. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.
ISSN:1549-3296
1552-4965
1552-4965
DOI:10.1002/jbm.a.32905