Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis

Background and Purpose:  The A>G polymorphism at position 19911 of the prothrombin gene is associated with a mildly increased risk of venous thromboembolism, alone or in association with such common thrombophilia mutations as factor V Leiden and prothrombin 20210 GA. Its role in cerebral sinus‐ve...

Full description

Saved in:
Bibliographic Details
Published in:European journal of neurology 2010-12, Vol.17 (12), p.1482-1485
Main Authors: Martinelli, I., Bucciarelli, P., De Stefano, V., Passamonti, S. M., Menegatti, M., Tormene, D., Tosetto, A., Mannucci, P. M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Case-Control Studies
cerebral vein thrombosis
Child
Child, Preschool
Coagulation
Coagulation factors
Factor V
Factor V - genetics
factor V Leiden
Female
Gene polymorphism
Genetic Predisposition to Disease
Health risk assessment
Humans
Infant
Male
Middle Aged
Mutation
Polymorphism, Genetic
prothrombin
Prothrombin - genetics
prothrombin gene
prothrombin mutation
Risk factors
Sinus Thrombosis, Intracranial - genetics
Thromboembolism
thrombophilia
Thrombophilia - genetics
Thrombosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Purpose:  The A>G polymorphism at position 19911 of the prothrombin gene is associated with a mildly increased risk of venous thromboembolism, alone or in association with such common thrombophilia mutations as factor V Leiden and prothrombin 20210 GA. Its role in cerebral sinus‐venous thrombosis (CSVT) is not known. Methods:  The presence of prothrombin 19911 A>G was investigated in a case–control study of 107 patients with cerebral thrombosis and factor V Leiden (n = 25), prothrombin 20210 GA (n = 47), without known thrombophilia (n = 35) and 842 healthy individuals with the corresponding coagulation profile. Results:  Prothrombin 19911 A>G did not increase the risk of CSVT in carriers of factor V Leiden (adjusted odds ratio 1.6, 95%CI 0.6–4.7), prothrombin 20210 GA (odds ratio 1.1, 95%CI 0.6–2.2), nor in patients without known thrombophilia (odds ratio 1.3, 95%CI 0.5–3.1). Conclusions:  Prothrombin 19911 A>G polymorphism does not appear to be a risk factor for CSVT, alone or in association with factor V Leiden or prothrombin 20210GA.
ISSN:1351-5101
1468-1331
DOI:10.1111/j.1468-1331.2010.03068.x