Disseminated Carcinoma Diagnosed by Bone Marrow Biopsy in Patients with Microangiopathic Hemolytic Anemia and Thrombocytopenia: A Report of Two Cases with Gastric Cancer and a Review of the Literature

Introduction Malignancy is often associated with hematological disorders, but rarely is the diagnosis of malignancy secondary to the diagnosis of microangiopathic hemolytic anemia and thrombocytopenia. Case reports We report hereby two patients with metastatic gastric carcinoma presenting with micro...

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Published in:Journal of gastrointestinal cancer 2011-09, Vol.42 (3), p.123-126
Main Authors: Kaidar-Person, Orit, Nasrallah, Haitam, Haim, Nissim, Dann, Eldad J., Bar-Sela, Gil
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adult
Biopsy
Bone Marrow - pathology
Cancer Research
Fatal Outcome
Female
Gastroenterology
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Purpura, Thrombotic Thrombocytopenic - diagnosis
Purpura, Thrombotic Thrombocytopenic - therapy
Radiotherapy
Review Article
Stomach Neoplasms - diagnosis
Thrombocytopenia - diagnosis
Thrombocytopenia - therapy
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Summary:Introduction Malignancy is often associated with hematological disorders, but rarely is the diagnosis of malignancy secondary to the diagnosis of microangiopathic hemolytic anemia and thrombocytopenia. Case reports We report hereby two patients with metastatic gastric carcinoma presenting with microangiopathic hemolytic anemia and thrombocytopenia. Despite chemotherapy and repeated plasmapheresis in one patient, both patients succumbed shortly after the diagnosis of cancer was made. Conclusion A review of the literature regarding microangiopathic hemolytic anemia in cancer patients is discussed. In patients suffering from microangiopathic hemolytic anemia and thrombocytopenia, malignancy should be considered as a possible cause. Early diagnosis of malignancy may be critical for determining the patient’s prognosis and potentially avoiding unnecessary overtreatment.
ISSN:1941-6628
1941-6636
DOI:10.1007/s12029-010-9204-6