Risk for perioperative myocardial infarction and mortality in patients undergoing hip or knee arthroplasty: the role of anemia

BACKGROUND: Anemia is common in patients undergoing surgery. This study was designed to determine whether preoperative anemia represents an independent risk factor for 30‐day mortality and nonfatal myocardial infarction (death/MI) in patients undergoing major orthopedic arthroplasty surgery. STUDY D...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2011-01, Vol.51 (1), p.82-91
Main Authors: Mantilla, Carlos B., Wass, C. Thomas, Goodrich, Karissa A., Johanns, Cassie J., Kool, Michelle L., Zhu, Xun, Corredor, Jose A., Warner, David O., Joyner, Michael J., Berry, Daniel J., Schroeder, Darrell R., Sprung, Juraj
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
anemia
Anemia - etiology
Anemia - physiopathology
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Arthroplasty, Replacement, Hip - adverse effects
Arthroplasty, Replacement, Knee - adverse effects
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Cardiology. Vascular system
Case-Control Studies
Coronary heart disease
Female
Heart
Hemoglobins - metabolism
Humans
Male
Medical sciences
Mortality
myocardial infarction
Myocardial Infarction - mortality
Myocardial Infarction - surgery
Postoperative Complications
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:BACKGROUND: Anemia is common in patients undergoing surgery. This study was designed to determine whether preoperative anemia represents an independent risk factor for 30‐day mortality and nonfatal myocardial infarction (death/MI) in patients undergoing major orthopedic arthroplasty surgery. STUDY DESIGN AND METHODS: Between January 1987 and December 2006 at the Mayo Clinic, 391 orthopedic patients experienced death/MI within 30 days of the index surgery. For each patient included in the event cohort (case), one control patient (1:1 ratio) was identified matched according to sex, age, type of joint operation (hip vs. knee vs. bilateral knee), primary operation versus revision, emergent versus elective, and date of surgery. Association of preoperative hemoglobin (Hb) with death/MI was assessed by multiple linear regression including preoperative Hb and all other characteristics and comorbid conditions found to have some evidence (p 
ISSN:0041-1132
1537-2995
DOI:10.1111/j.1537-2995.2010.02797.x