SP-A1, SP-A2 and SP-D gene polymorphisms in severe acute respiratory syncytial infection in Chilean infants

► In this work, polymorphisms of SP-A1, SP-A2 and SP-D genes, was performed in Chilean infants with RSV-ALRI. ► Infants- SNP comparison was done according to their clinical severity and with general population. ► This is a study of genetic susceptibility for RSV infection in South-American populatio...

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Published in:Infection, genetics and evolution genetics and evolution, 2011-08, Vol.11 (6), p.1368-1377
Main Authors: Ampuero, Sandra, Luchsinger, Vivian, Tapia, Lorena, Palomino, María Angélica, Larrañaga, Carmen E.
Format: Article
Language:English
Subjects:
alleles
Biological and medical sciences
biomarkers
blood
Case-Control Studies
children
Chile
Epidemiology. Vaccinations
Female
Gene Frequency
General aspects
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
heterozygosity
Human viral diseases
Humans
Infant
infants
Infectious diseases
Male
Medical sciences
pathogens
Polymorphism, Single Nucleotide
prospective studies
Pulmonary collectins
Pulmonary Surfactant-Associated Protein A - genetics
Pulmonary Surfactant-Associated Protein D - genetics
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - genetics
respiratory tract diseases
Risk Factors
Severe infantile respiratory infection
Single nucleotide polymorphism
Statistics, Nonparametric
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
viruses
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Summary:► In this work, polymorphisms of SP-A1, SP-A2 and SP-D genes, was performed in Chilean infants with RSV-ALRI. ► Infants- SNP comparison was done according to their clinical severity and with general population. ► This is a study of genetic susceptibility for RSV infection in South-American population. ► Differences found with other authors, indicates the need to identify local biomarkers of severity. Respiratory syncytial virus (RSV) is the principal pathogen that causes acute lower respiratory tract infection (ALRI) in infants. Severe RSV-ALRI has been associated with the host genetic susceptibility. To assess whether severe RSV disease in infants is associated with certain single nucleotide polymorphism (SNP) into the gene of SP-A1, SP-A2 and SP-D, a prospective study was performed among blood donors and RSV-infected infants aged
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2011.04.033