Usefulness of Peripheral Vascular Function to Predict Functional Health Status in Patients With Fontan Circulation

After the Fontan operation, patients are at a substantial risk of the development of impaired functional health status. Few early markers of suboptimal outcomes have been identified. We sought to assess the association between peripheral vascular function and functional health status in Fontan-palli...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2011-08, Vol.108 (3), p.428-434
Main Authors: Goldstein, Bryan H., MD, Golbus, Jessica R, Sandelin, Angela M, Warnke, Nicole, BS, Gooding, Lindsay, BS, King, Karen K., CCRC, Donohue, Janet E., MPH, Gurney, James G., PhD, Goldberg, Caren S., MD, MS, Rocchini, Albert P., MD, Charpie, John R., MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Biomarkers
Blood Pressure - physiology
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Child
Child, Preschool
Disability Evaluation
Echocardiography, Doppler
Endothelium, Vascular - physiopathology
Exercise Test
Female
Fingers - blood supply
Fontan Procedure
Health Status
Humans
Hyperemia - physiopathology
Male
Manometry
Medical sciences
Nitric Oxide - physiology
Oxygen
Oxygen - blood
Patients
Peripheral Vascular Diseases - diagnosis
Peripheral Vascular Diseases - physiopathology
Postoperative Complications - diagnosis
Postoperative Complications - physiopathology
Prognosis
Prospective Studies
Pulse
Quality of Life
Reference Values
Vascular Resistance - physiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:After the Fontan operation, patients are at a substantial risk of the development of impaired functional health status. Few early markers of suboptimal outcomes have been identified. We sought to assess the association between peripheral vascular function and functional health status in Fontan-palliated patients. Asymptomatic Fontan patients (n = 51) and age- and gender-matched healthy controls (n = 22) underwent endothelial pulse amplitude testing using a noninvasive fingertip peripheral arterial tonometry (PAT) device. Raw data were transformed into the PAT ratio, an established marker of vascular function. Cardiopulmonary exercise testing was performed using the Bruce protocol. In the Fontan cohort, 94% of patients were New York Heart Association functional class I and 88% had a B-type natriuretic peptide level of
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2011.03.064