One-Pot Synthesis of an 125I-Labeled Trifunctional Reagent for Multiscale Imaging with Optical and Nuclear Techniques

A highly efficient and rapid CuII‐mediated three‐component “click reaction” allows one‐pot assembly of dual optical and nuclear labeling reagents. Proof‐of‐concept imaging studies demonstrate that the distribution of the dual‐labeled antibody A5B7 can be interrogated from the cellular to the macrosc...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2011-07, Vol.50 (30), p.6793-6795
Main Authors: Yan, Ran, El-Emir, Ethaar, Rajkumar, Vineeth, Robson, Mathew, Jathoul, Amit P., Pedley, R. Barbara, Årstad, Erik
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - analysis
Antibodies, Monoclonal - chemistry
Carcinoembryonic Antigen - analysis
click chemistry
Click Chemistry - methods
Copper - chemistry
Diagnostic Imaging - methods
Fluorescence
Humans
imaging agents
Indium Radioisotopes - chemistry
iodotriazoles
Mice
Neoplasms - diagnosis
radiochemistry
Triazoles - chemistry
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Description
Summary:A highly efficient and rapid CuII‐mediated three‐component “click reaction” allows one‐pot assembly of dual optical and nuclear labeling reagents. Proof‐of‐concept imaging studies demonstrate that the distribution of the dual‐labeled antibody A5B7 can be interrogated from the cellular to the macroscopic level using a combination of optical and nuclear imaging techniques.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201102072