Investigating the reproducibility of the novel Alpha-5 GABAA receptor PET ligand [11C]Ro15 4513

Arterial plasma input function (IFs) were obtained by continuous blood withdrawal for 15min and combination with discrete plasma samples for correction of radio-labelled metabolites and incorporation of plasma-over-blood ratio within Clickfit Software (MRC Cyclotron Unit, Hammersmith, London, UK). 0...

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Published in:NeuroImage (Orlando, Fla.) Fla.), 2010-08, Vol.52 (S1), p.S112-S112
Main Authors: Barros, D.A. Riaño, Heckemann, R.A., Rosso, L., McGinnity, C.J., Keihaninejad, S., Gousias, I.S., Brooks, D.J., Duncan, J.S., Koepp, M.J., Turkheimer, F.E., Hammers, A.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Reproducibility
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Summary:Arterial plasma input function (IFs) were obtained by continuous blood withdrawal for 15min and combination with discrete plasma samples for correction of radio-labelled metabolites and incorporation of plasma-over-blood ratio within Clickfit Software (MRC Cyclotron Unit, Hammersmith, London, UK). 0.0008 s-1 0.00063 s-1 0.0008 s-1 0.00063 s-1 0.0008 s-1 0.00063 s-1 Hippocampus 0.38 0.96 12% 16% 15% (-10.8 - 22.5) 14% (-15.5 - 19.0) Amygdala 0.26 0.95 14% 18% 16% (-9.5 - 25.2) 4% (-96 - 6.6) Insula 0.01 0.95 10% 11% 13% (-12.4 - 16.9) 2% (-7.9 - 1.0) Anterior Cingulate Gyrus -0.12 0.89 10% 11% 15% (-14.4 - 19.6) 4% (-7.2 - 6.8) Cerebellum -0.03 0.38 12% 13% 14% (-11.8 - 23.9) 14% (-9.5 - 24.8) Table 1 Comparison between intraclass correlation coefficients (ICC), coefficients of variation (CV; expressed as percentages) and the average percentage test-retest differences in VD (expressed as percentages with range) between-subjects coefficients by bilateral regions of interest, for the various cut-off frequencies.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.04.091