Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia

Highlights ► This study addresses the need for an objective assessment tool evaluating prefrontal function and social outcome non-invasively in the clinical setting. ► Such a tool would be valuable for studies of the pathophysiology of schizophrenia and in the evaluation of patients with schizophren...

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Published in:Clinical neurophysiology 2011-08, Vol.122 (8), p.1533-1540
Main Authors: Koike, Shinsuke, Takizawa, Ryu, Nishimura, Yukika, Marumo, Kohei, Kinou, Masaru, Kawakubo, Yuki, Rogers, Mark A, Kasai, Kiyoto
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Age at onset
Biological and medical sciences
Brain Mapping
Case-Control Studies
Cognition Disorders - etiology
Cognition Disorders - pathology
Electrodiagnosis. Electric activity recording
Female
Functional Laterality
Humans
Imaging, Three-Dimensional
Investigative techniques, diagnostic techniques (general aspects)
Male
Mathematics
Medical sciences
Middle Aged
Near-infrared spectroscopy (NIRS)
Nervous system
Neurology
Neuropsychological Tests
Oxyhemoglobins - metabolism
Prefrontal Cortex - metabolism
Prefrontal Cortex - physiopathology
Prefrontal cortical haemodynamics
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Random number generation (RNG)
Reaction Time - physiology
Schizophrenia
Schizophrenia - complications
Severity of Illness Index
Short-term memory
Spectroscopy, Near-Infrared - methods
Young Adult
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Summary:Highlights ► This study addresses the need for an objective assessment tool evaluating prefrontal function and social outcome non-invasively in the clinical setting. ► Such a tool would be valuable for studies of the pathophysiology of schizophrenia and in the evaluation of patients with schizophrenia. ► Multichannel near-infrared spectroscopy is a non-invasive and user-friendly instrument, and may be useful in evaluating cognitive function and social outcome in clinical settings in psychiatry.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2010.12.056