Immunoglobulin M antibodies against CRA and FRA recombinant antigens of Trypanosoma cruzi in chronic chagasic patients

Abstract Previous works of our research group have demonstrated aspects of the humoral immune response of chronic Chagas disease using the cytoplasmatic repetitive antigen (CRA) and the flagellar repetitive antigen (FRA) of Trypanosoma cruzi . The aim of this work was to analyze the presence of spec...

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Bibliographic Details
Published in:Human immunology 2011-05, Vol.72 (5), p.402-405
Main Authors: Vasconcelos, Romero H.T, Azevedo, Elisa A.N, Cavalcanti, Maria G.A.M, Silva, Edimilson D, Ferreira, Antonio G.P, Morais, Clarice N.L, Gomes, Yara M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens, Protozoan - genetics
Antigens, Protozoan - immunology
Antigens, Protozoan - metabolism
Chagas Cardiomyopathy
Chagas disease
Chagas Disease - classification
Chagas Disease - diagnosis
Chagas Disease - immunology
Chagas Disease - physiopathology
Chronic Disease
Disease Progression
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin M
Immunoglobulin M - blood
Prognosis
Protozoan Proteins - genetics
Protozoan Proteins - immunology
Protozoan Proteins - metabolism
Recombinant antigens
Recombinant Proteins - genetics
Trypanosoma cruzi
Trypanosoma cruzi - immunology
Trypanosoma cruzi - pathogenicity
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Summary:Abstract Previous works of our research group have demonstrated aspects of the humoral immune response of chronic Chagas disease using the cytoplasmatic repetitive antigen (CRA) and the flagellar repetitive antigen (FRA) of Trypanosoma cruzi . The aim of this work was to analyze the presence of specific immunoglobulin M (IgM) antibodies in chronic chagasic patients using these recombinant antigens of T. cruzi . The positivity of IgM in chronic chagasic patients against CRA and FRA antigens was determined by indirect enzyme-linked immunosorbent assay. We reported no statistical significant differences between the levels of IgM for both recombinant antigens and the different chronic clinical forms of Chagas disease. However, a small proportion of chronic chagasic patients analyzed in this study was positive for this antibody isotype. The findings of this study indicate that the IgM antibodies cannot be used to elucidate the differences in the profile of humoral immune response among chronic chagasic patients with different clinical forms using the CRA and FRA recombinant antigens of T. cruzi.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2011.02.015