Prognostic value of intercellular adhesion molecule (ICAM)-1 expression in breast cancer

Purpose The intercellular adhesion molecule (ICAM)-1 is expressed on many cell types including endothelial cells and different cancer cell entities. Experimental data strongly indicate that ICAM-1 can activate intracellular signalling pathways in cancer cells leading to enhanced cell motility, invas...

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Published in:Journal of cancer research and clinical oncology 2011-08, Vol.137 (8), p.1193-1201
Main Authors: Schröder, Christine, Witzel, Isabell, Müller, Volkmar, Krenkel, Sylke, Wirtz, Ralph M., Jänicke, Fritz, Schumacher, Udo, Milde-Langosch, Karin
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic agents
Biological and medical sciences
Biomarkers, Tumor - chemistry
Biomarkers, Tumor - genetics
Blotting, Western
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - chemistry
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Cancer Research
Carcinoma, Ductal, Breast - chemistry
Carcinoma, Ductal, Breast - pathology
Carcinoma, Lobular - chemistry
Carcinoma, Lobular - pathology
Disease-Free Survival
Enzyme-Linked Immunosorbent Assay
Female
Gene Expression Regulation, Neoplastic
Gynecology. Andrology. Obstetrics
Hematology
Humans
Immunohistochemistry
Intercellular Adhesion Molecule-1 - chemistry
Intercellular Adhesion Molecule-1 - genetics
Internal Medicine
Ki-67 Antigen - analysis
Lymphatic Metastasis
Mammary gland diseases
Medical prognosis
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Oncology
Original Paper
Pharmacology. Drug treatments
Plasminogen Activator Inhibitor 1 - analysis
Predictive Value of Tests
Prognosis
Protein Array Analysis - methods
Proteins
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
RNA, Messenger - analysis
Treatment Outcome
Tumors
Up-Regulation
Urokinase-Type Plasminogen Activator - analysis
Vascular Endothelial Growth Factor A - analysis
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Summary:Purpose The intercellular adhesion molecule (ICAM)-1 is expressed on many cell types including endothelial cells and different cancer cell entities. Experimental data strongly indicate that ICAM-1 can activate intracellular signalling pathways in cancer cells leading to enhanced cell motility, invasion and metastasis. Yet, little is known about the role of ICAM-1 expression during malignant progression in breast cancer patients. Methods We investigated ICAM-1 protein and mRNA expression in two partly overlapping cohorts of breast cancer patients. ICAM-1 protein was detected by Western blot analysis in 104 cases and verified by immunohistochemistry. Additionally, ICAM-1 mRNA microarray data from 169 tumours were analysed. Results With both methods, high ICAM-1 expression was significantly associated with a poorly differentiated phenotype, a negative estrogen receptor (ER) status and positive lymph node involvement. In addition, there was a significant prognostic impact of ICAM-1 protein overexpression on recurrence-free survival (HR = 2.82, P  = 0.023), which was most pronounced in ER-negative tumours. ICAM-1 mRNA overexpression was associated with high urokinase plasminogen activator (uPA) and uPA-inhibitor protein 1 (PAI 1) protein and mRNA levels as well as high Ki67 protein and vascular endothelial growth factor (VEGF) mRNA expression. Conclusions In our group of patients, ICAM-1 expression was associated with a more aggressive tumour phenotype. Because of its association with malignant progression, ICAM-1 might represent a new target in the treatment of breast cancer patients.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-011-0984-2