MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10

Abstract MicroRNAs are small endogenous noncoding RNAs, which modulate target gene expression by binding with target mRNA sequences in the 3′untranslated region (UTR) with an imperfect complementarity that inhibits the mRNA translation. Many microRNAs have been reported to function as tumor oncogene...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2011-05, Vol.1389, p.9-18
Main Authors: Sun, Lihua, Yan, Wei, Wang, Yingyi, Sun, Guan, Luo, Hui, Zhang, Junxia, Wang, Xiefeng, You, Yongping, Yang, Zhengxiang, Liu, Ning
Format: Article
Language:English
Subjects:
Anti-oncogenes
Antisense oligonucleotides
Apoptosis
Biological and medical sciences
Blotting, Western
brain
Brain tumors
cell invasion
Cell Line, Tumor
Complementarity
Gene Expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Glioma
Glioma - genetics
Glioma - metabolism
Glioma - pathology
Glioma cells
Homeodomain Proteins - biosynthesis
HOXD10
Humans
Invasion
Malignancy
Matrix Metalloproteinase 14 - biosynthesis
Medical sciences
MicroRNA
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
MMP-14
Neoplasm Invasiveness - genetics
Neurology
non-coding RNA
nucleotide sequences
oligonucleotides
Oncogenes
Receptors, Urokinase Plasminogen Activator - biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Signal transduction
Signal Transduction - physiology
Transcription Factors - biosynthesis
Translation
translation (genetics)
tumor suppressor genes
Tumors
Tumors of the nervous system. Phacomatoses
uPAR
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract MicroRNAs are small endogenous noncoding RNAs, which modulate target gene expression by binding with target mRNA sequences in the 3′untranslated region (UTR) with an imperfect complementarity that inhibits the mRNA translation. Many microRNAs have been reported to function as tumor oncogenes or anti-oncogenes. Recently, more and more microRNAs have been reported to contribute to a tumor's invasive potential. Here, we show that microRNA-10b (miR-10b) was over-expressed in glioma samples and directly associated with the glioma's pathological grade and malignancy. We also found that miR-10b induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10. The miR-10b/HOXD10/MMP-14/uPAR signaling pathway might contribute to the invasion of glioma. Accordingly, glioma cells lost their invasive ability when treated with specific antisense oligonucleotides (miR-10b inhibitors), suggesting that miR-10b could be used as a new bio-target to cure glioma.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2011.03.013