A novel hydroxyapatite ceramic bone substitute transformed by ostrich cancellous bone: Characterization and evaluations of bone regeneration activity

Various biomaterials have been used for bone repair and reconstruction of bone defects. Inorganic xenogenic bone substitutes have been intensively studied because they possesses favorable regenerative properties. The purpose of this study was to evaluate the properties of a novel inorganic xenogenic...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2011-08, Vol.98B (2), p.217-222
Main Authors: Sawada, Yasunori, Hokugo, Akishige, Yang, Yaowu, Kamitani, Masayuki, Matsuda, Sakiko, Mao, Tianqiu, Lei, Delin, Chen, Fulin, Iseki, Tomio, Morita, Shosuke
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomechanical Phenomena
Bone and Bones
Bone Regeneration
bone substitute
Bone Substitutes - chemistry
Durapatite - chemistry
Durapatite - therapeutic use
Materials Testing
Medical sciences
Orthopedic surgery
ostrich
Rabbits
Struthioniformes
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Transplantation, Heterologous
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Summary:Various biomaterials have been used for bone repair and reconstruction of bone defects. Inorganic xenogenic bone substitutes have been intensively studied because they possesses favorable regenerative properties. The purpose of this study was to evaluate the properties of a novel inorganic xenogenic bone substitute, sintered ostrich cancellous bone (SOCB). Bone regeneration capability was also comparing to that of other bone substitutes in rabbit calvarial defects. Biochemical and biomechanical properties of the SOCB ceramic closely resembled those of human bone. Bone regeneration was evaluated by radiograph, histology, and histomorphometry. Bone regeneration was significantly enhanced in defects treated with SOCB when compared with other bone substitutes. The biochemical and biomechanical properties of SOCB are favorable for bone regeneration. SOCB might be a promising biomaterial for the repair of bone defects. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
ISSN:1552-4973
1552-4981
1552-4981
DOI:10.1002/jbm.b.31783