Mapping the networks for pluripotency

There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play essential roles, and signalling pathways also act t...

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Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2011-08, Vol.366 (1575), p.2238-2246
Main Authors: Xue, Kun, Ng, Jia-Hui, Ng, Huck-Hui
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cell lines
Cells
Cellular differentiation
Cultured cells
Embryonic Stem Cell
Embryonic stem cells
Gene Expression Regulation - physiology
Genes
Ground state
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Mouse Embryonic Stem Cell-Like Interconversion
Pluripotency
Pluripotent stem cells
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Signal Transduction - physiology
Signalling Pathways
Stem cells
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
Transcriptional Network
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Summary:There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play essential roles, and signalling pathways also act to sustain the undifferentiated state. Recent studies have unravelled multiple forms of interconnection and crosstalk between these two regulatory aspects of pluripotency. With the discovery of epiblast stem cells, there is an emerging concept that different pluripotent states could exist, and knowledge of both transcriptional networks and signalling pathways has been vital in dissecting the properties of these different states. Similar to classical reprogramming methodologies, various combinations of transcription factor transduction and the modulation of intracellular signalling have enabled the interconversion between pluripotent states. These studies provide an insight into the defining characteristics as well as the plasticity of pluripotent cells.
ISSN:0962-8436
1471-2970
DOI:10.1098/rstb.2011.0005