Loading…
High-dose dexmedetomidine increases the opioid-free interval and decreases opioid requirement after tonsillectomy in children
Purpose Dexmedetomidine, a selective α 2 adrenoreceptor agonist, has analgesic and sedative properties, minimal impact on respiratory parameters, and reportedly decreases analgesic requirements after surgery. Given its pharmacodynamic profile, dexmedetomidine might have a role for postoperative pain...
Saved in:
Published in: | Canadian journal of anesthesia 2011-06, Vol.58 (6), p.540-550 |
---|---|
Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Purpose
Dexmedetomidine, a selective α
2
adrenoreceptor agonist, has analgesic and sedative properties, minimal impact on respiratory parameters, and reportedly decreases analgesic requirements after surgery. Given its pharmacodynamic profile, dexmedetomidine might have a role for postoperative pain control in children undergoing tonsillectomy. In this study, we hypothesized that dexmedetomidine would delay and decrease opioid requirements after tonsillectomy.
Methods
In a double-blind controlled trial, participants undergoing tonsillectomy were randomized to receive one intravenous dose of fentanyl (1 μg·kg
−1
or 2 μg·kg
−1
) or dexmedetomidine (2 μg·kg
−1
or 4 μg·kg
−1
) immediately after endotracheal intubation. Primary outcomes included requirement for rescue morphine in the initial postoperative period.
Results
One hundred and one children were enrolled. During the postoperative period, dexmedetomidine (2 and 4 μg·kg
−1
groups combined) significantly prolonged the opioid-free interval of children who underwent tonsillectomy compared with fentanyl (1 and 2 μg·kg
−1
groups combined) (
P
|
---|---|
ISSN: | 0832-610X 1496-8975 |
DOI: | 10.1007/s12630-011-9493-7 |