Epidemiological changes in hepatitis B prevalence in an entire population after 20 years of the universal HBV vaccination programme

A universal hepatitis B vaccination programme has been conducted in Long An county since 1986. To investigate the epidemiological changes in hepatitis B virus (HBV) infection we conducted a serosurvey there in 2005. A total of 4686 subjects were enrolled and vaccination history and blood samples col...

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Bibliographic Details
Published in:Epidemiology and infection 2011-08, Vol.139 (8), p.1159-1165
Main Authors: SHEN, L. P., ZHANG, Y., WANG, F., ZHANG, S., YANG, J. Y., FANG, K. X., YU, T., WANG, X. Y., ZHANG, W. Y., BI, S. L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age groups
Aged
Aged, 80 and over
Biological and medical sciences
Biological products
Child
Child, Preschool
Children
China - epidemiology
Dosage
Epidemiology
Ethics
Female
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis antigens
Hepatitis B
Hepatitis B - epidemiology
Hepatitis B - prevention & control
Hepatitis B Surface Antigens - blood
Hepatitis B Vaccines - administration & dosage
Hepatitis B Vaccines - immunology
Hepatitis B virus
Hepatitis C Antibodies - blood
Human viral diseases
Humans
Immunization
Infant
Infections
Infectious diseases
Liver cancer
Liver cirrhosis
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Pilot projects
Population
Questionnaires
Radioimmunoassay
REVIEW ARTICLE
Seroepidemiologic Studies
Vaccination
Vaccines
Viral diseases
Viral hepatitis
Virology
Young Adult
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Summary:A universal hepatitis B vaccination programme has been conducted in Long An county since 1986. To investigate the epidemiological changes in hepatitis B virus (HBV) infection we conducted a serosurvey there in 2005. A total of 4686 subjects were enrolled and vaccination history and blood samples collected. HBV infective markers were determined by radioimmunoassay. The results were compared with the data of 1985. Our results show that the overall HBsAg prevalence was 7·5%, less than half of the prevalence reported in 1985. HBsAg and anti-HBc antibody prevalence in people born after 1985 decreased markedly. The gender difference in HBsAg prevalence was abolished in subjects aged
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268810002827