Tryptase-positive mast cells and CD8-positive T cells in human endometrial cancer

In this study, we correlated the number of tryptase‐reactive mast cells with the number of CD8‐positive T cells in human endometrial adenocarcinoma biopsy specimens by means of immunohistochemical techniques. Results have shown that CD8‐positive T cell counts correlate to tryptase‐positive mast cell...

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Bibliographic Details
Published in:Pathology international 2011-07, Vol.61 (7), p.442-444
Main Authors: Ribatti, Domenico, Nico, Beatrice, Finato, Nicoletta, Crivellato, Enrico
Format: Article
Language:English
Subjects:
Adenocarcinoma - immunology
Adenocarcinoma - pathology
CD19+ B cells
CD8+ T cells
CD8-Positive T-Lymphocytes - pathology
Disease Progression
endometrial adenocarcinoma
Endometrial Neoplasms - immunology
Endometrial Neoplasms - pathology
Female
Humans
inflammation
mast cells
Mast Cells - enzymology
Mast Cells - immunology
Mast Cells - pathology
Neoplasm Invasiveness
Neoplasm Staging
tumor progression
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Summary:In this study, we correlated the number of tryptase‐reactive mast cells with the number of CD8‐positive T cells in human endometrial adenocarcinoma biopsy specimens by means of immunohistochemical techniques. Results have shown that CD8‐positive T cell counts correlate to tryptase‐positive mast cell counts and that these parameters increase in accordance with the tumor progression of human endometrial carcinoma. These data suggest that inhibition of inflammation or manipulation of inflammatory resolution pathways may be a new therapeutic approach for the treatment of endometrial adenocarcinoma.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2011.02680.x