Expression of endometrial protein markers in infertile women and the association with subsequent in vitro fertilization outcome

Endometrial biopsies were performed during the luteal phase just before an IVF cycle in 104 infertile women, and immunohistochemical staining was performed to investigate expression patterns of hCG-LH receptor, leukemia-inhibitory factor, macrophage colony-stimulating factor, HOXA-10, vascular endot...

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Bibliographic Details
Published in:Fertility and sterility 2011-06, Vol.95 (8), p.2707-2710
Main Authors: Seo, Won Seok, M.D, Jee, Byung Chul, M.D, Moon, Shin Yong, M.D
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - analysis
Biopsy
Birth control
Case-Control Studies
endometrium
Endometrium - chemistry
Endometrium - physiopathology
Female
Fertilization in Vitro
Gynecology. Andrology. Obstetrics
Homeodomain Proteins - analysis
Humans
Immunohistochemistry
implantation
in vitro fertilization
Infertility
Infertility - metabolism
Infertility - physiopathology
Infertility - therapy
Internal Medicine
Leukemia Inhibitory Factor - analysis
Luteal Phase - metabolism
macrophage colony-stimulating factor
Macrophage Colony-Stimulating Factor - analysis
Male
Medical sciences
Obstetrics and Gynecology
prediction
Pregnancy
Pregnancy Rate
Receptors, LH - analysis
Republic of Korea
Sterility. Assisted procreation
Treatment Outcome
Up-Regulation
vascular endothelial growth factor A
Vascular Endothelial Growth Factor A - analysis
VEGF
women
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Summary:Endometrial biopsies were performed during the luteal phase just before an IVF cycle in 104 infertile women, and immunohistochemical staining was performed to investigate expression patterns of hCG-LH receptor, leukemia-inhibitory factor, macrophage colony-stimulating factor, HOXA-10, vascular endothelial growth factor A, and their relation to subsequent IVF pregnancy. Only glandular expression of vascular endothelial growth factor A in early luteal endometrium was significantly higher in the pregnant group compared with the nonpregnant group (6.0 ± 3.9 vs. 2.9 ± 3.4) and thus could be a predicting marker for subsequent IVF pregnancy.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2011.01.009