The Effects of Biliopancreatic Diversion on Type 2 Diabetes Mellitus in Patients with Mild Obesity (BMI 30–35 kg/m2) and Simple Overweight (BMI 25–30 kg/m2): A Prospective Controlled Study

Background Beneficial effects of BPD on T2DM in BMI >35 kg/m 2 patients are far better than those in patients with BMI 25–35. This study was aimed at investigating if a similar difference exists between patients with mild obesity (OB, BMI 30–35) or simple overweight (OW, BMI 25–30). Methods Fifte...

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Bibliographic Details
Published in:Obesity surgery 2011-07, Vol.21 (7), p.880-888
Main Authors: Scopinaro, Nicola, Adami, Giovanni F., Papadia, Francesco S., Camerini, Giovanni, Carlini, Flavia, Briatore, Lucia, D’Alessandro, Gabriele, Parodi, Corrado, Weiss, Andrea, Andraghetti, Gabriella, Catalano, Mariafrancesca, Cordera, Renzo
Format: Article
Language:English
Subjects:
Adult
Aged
Biliopancreatic Diversion
Blood Glucose - metabolism
Body Mass Index
Clinical Research
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Female
Gastrointestinal surgery
Glycated Hemoglobin A - metabolism
Humans
Insulin - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Obesity
Obesity - blood
Obesity - complications
Obesity - surgery
Overweight - blood
Overweight - complications
Overweight - surgery
Prospective Studies
Surgery
Treatment Outcome
Weight Loss
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Summary:Background Beneficial effects of BPD on T2DM in BMI >35 kg/m 2 patients are far better than those in patients with BMI 25–35. This study was aimed at investigating if a similar difference exists between patients with mild obesity (OB, BMI 30–35) or simple overweight (OW, BMI 25–30). Methods Fifteen OB (six M) and 15 OW (13 M), diabetic for ≥3 years, with HbA1c ≥7.5% despite medical therapy, underwent BPD. OB/OW: age 55.1 ± 8.0/57.8 ± 6.7 years, BMI 33.1 ± 1.5/28.0 ± 1.3 kg/m 2 , diabetes duration 11.6 ± 8.0/11.1 ± 6.1 years, insulin therapy 4/8 p. FSG and HbA1c were determined preoperatively and up to 2 years. Insulin resistance and beta-cell function were explored by means of HOMA-IR and IVGTT (AIR). Thirty-eight diabetic patients on medical therapy served as controls. Results Mean BMI stabilized around 27 since the 4th month in OB, and 24 since 1st month in OW. FSG in OB/OW preop, 1, 12, 24 months: 234 ± 76/206 ± 62 mg/dL, 154 ± 49/176 ± 75, 131 ± 32/167 ± 48, 134 ± 41/154 ± 41 (cross-sectional n.s. at all times); HbA1c: 9.5 ± 1.6/9.1 ± 1.3, 7.3 ± 1.1/7.3 ± 1.2, 5.9 ± 0.6/7.1 ± 1.1 ( p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-011-0407-0