Blind randomized controlled study of the efficacy of cognitive training in Parkinson's disease

The aim of this study was to analyze the efficacy of a cognitive training program on cognitive performance and quality of life in nondemented Parkinson's disease patients. Participants who met UK Brain Bank diagnosis criteria for Parkinson's disease, with I–III Hoehn & Yahr, aged 50–80...

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Bibliographic Details
Published in:Movement disorders 2011-06, Vol.26 (7), p.1251-1258
Main Authors: París, Anna Prats, Saleta, Heidi Guerra, de la Cruz Crespo Maraver, Maria, Silvestre, Emmanuel, Freixa, Maite Garolera, Torrellas, Cristina Petit, Pont, Silvia Alonso, Nadal, Marc Fabra, Garcia, Sheila Alcaine, Bartolomé, Maria Victoria Perea, Fernández, Valentina Ladera, Bayés, Àngels Rusiñol
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
cognition
Cognition Disorders - psychology
Cognition Disorders - therapy
cognitive impairment
Cognitive Therapy - methods
cognitive training neuropsychology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Male
Medical sciences
Middle Aged
Neurology
Neuropsychological Tests
Parkinson Disease - psychology
Parkinson Disease - therapy
Parkinson's disease
Quality of Life
Treatment Outcome
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Summary:The aim of this study was to analyze the efficacy of a cognitive training program on cognitive performance and quality of life in nondemented Parkinson's disease patients. Participants who met UK Brain Bank diagnosis criteria for Parkinson's disease, with I–III Hoehn & Yahr, aged 50–80, and nondemented (Mini‐Mental State Examination ≥ 23) were recruited. Patient's cognitive performance and functional and quality‐of‐life measures were assessed with standardized neuropsychological tests and scales at baseline and after 4 weeks. Subjects were randomly and blindly allocated by age and premorbid intelligence (Vocabulary, Wechsler Adult Intelligence Scale‐III) into 2 groups: an experimental group and a control group. The experimental group received 4 weeks of 3 weekly 45‐minute sessions using multimedia software and paper‐and‐pencil cognitive exercises, and the control group received speech therapy. A total of 28 patients were analyzed. Compared with the control group participants (n = 12), the experimental group participants (n = 16) demonstrated improved performance in tests of attention, information processing speed, memory, visuospatial and visuoconstructive abilities, semantic verbal fluency, and executive functions. There were no observable benefits in self‐reported quality of life or cognitive difficulties in activities of daily living. We concluded that intensive cognitive training may be a useful tool in the management of cognitive functions in Parkinson's disease. © 2011 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.23688