The ABC transporters in lipid flux and atherosclerosis

Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality in the United States and in many other countries. Dysfunctional lipid homeostasis plays a central role in the initiation and progression of atherosclerotic lesions. The ATP-binding cassette (ABC) transporters are...

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Bibliographic Details
Published in:Progress in lipid research 2011-07, Vol.50 (3), p.213-224
Main Authors: Voloshyna, Iryna, Reiss, Allison B.
Format: Article
Language:English
Subjects:
ABC transporters
Animals
Apolipoprotein A
Atherosclerosis
Atherosclerosis - metabolism
ATP-Binding Cassette Transporters - metabolism
Biliary Tract - physiology
Biological Transport
Cholesterol - metabolism
Cholesterol, HDL - metabolism
Cholesterol, LDL - metabolism
High density lipoprotein
Humans
Lipid Metabolism
Liver X receptor (LXR)
Reverse cholesterol transport
Structure-Activity Relationship
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Summary:Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality in the United States and in many other countries. Dysfunctional lipid homeostasis plays a central role in the initiation and progression of atherosclerotic lesions. The ATP-binding cassette (ABC) transporters are transmembrane proteins that hydrolyze ATP and use the energy to drive the transport of various molecules across cell membranes. Several ABC transporters play a pivotal role in lipid trafficking. They are critically involved in cholesterol and phospholipid efflux and reverse cholesterol transport (RCT), processes that maintain cellular cholesterol homeostasis and protect arteries from atherosclerosis. In this article we provide a review of the current literature on the biogenesis of ABC transporters and highlight their proposed functions in atheroprotection.
ISSN:0163-7827
1873-2194
DOI:10.1016/j.plipres.2011.02.001