Prophylactic and curative effects of purslane on bile duct ligation-induced hepatic fibrosis in albino rats

Hepatic fibrosis is a common pathological process of chronic liver injury. Oxidative stress and inflammation may have prognostic value in disease progression. To examine the implication of both aforementioned factors in hepatic fibrosis progression and whether, the antioxidant effect of various biol...

Full description

Saved in:
Bibliographic Details
Published in:Annals of hepatology 2011-07, Vol.10 (3), p.340-346
Main Authors: Ali, Sousou I, Said, Mostafa M, Hassan, Ehsan Khedre Mohammed
Format: Article
Language:English
Subjects:
Administration, Oral
Albinism
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Antioxidants - therapeutic use
Bile Ducts - physiopathology
Bile Ducts - surgery
Cytokines - metabolism
Disease Models, Animal
Hepatic Stellate Cells - drug effects
Hepatic Stellate Cells - metabolism
Hepatic Stellate Cells - pathology
Ligation
Liver Cirrhosis - drug therapy
Liver Cirrhosis - etiology
Liver Cirrhosis - prevention & control
Oxidative Stress - drug effects
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Portulaca
Rats
Rats, Mutant Strains
Silymarin - administration & dosage
Silymarin - pharmacology
Silymarin - therapeutic use
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hepatic fibrosis is a common pathological process of chronic liver injury. Oxidative stress and inflammation may have prognostic value in disease progression. To examine the implication of both aforementioned factors in hepatic fibrosis progression and whether, the antioxidant effect of various biological active constituents such as phenolic, flavonoids and fatty acids of purslane hydro-ethanolic extract can represent a potential target for therapy. Purslane exhibited a considerable antioxidant potential in DPPH assay compared to α-tocopherol. Consequently, the current study was designed to examine the prophylactic and curative effects of purslane extract on bile duct ligation (BDL)-induced liver fibrosis in rats in comparison with silymarin as a reference hepatoprotective agent. Purslane (400 mg/kg/day) or silymarin (50 mg/kg/day) were administered orally for 4 weeks, immediately after surgery in order to evaluate the prophylactic effect and for 3 weeks starting 3 weeks after BDL in order to evaluate the curative effect. BDL significantly increased liver enzymes, total bilirubin (TB) and tumor necrosis factor-alpha (TNF-α) in serum along with malondialdehyde (MDA) in liver tissues. Significant decrease in hepatic antioxidant defense system was noted in BDL-rats. Conversely, administration of purslane reversed all these biochemical parameters which were previously induced by BDL. Considerably, purslane effect was more pronounced in the prophylactic study than that in the curative one. The present work suggested that purslane had prophylactic and curative value on cholestasis-induced liver fibrosis through inhibition of oxidative stress, decreasing the expression of profibrogenic cytokines, collagenolytic activity and activation of hepatic stellate cells.
ISSN:1665-2681
2659-5982
DOI:10.1016/s1665-2681(19)31547-9