Local allergic rhinitis: Allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen

Currently, the majority of patients with LAR are treated with allergen avoidance measures and symptomatic medication with intranasal corticosteroids and oral antihistamines.E1E2 Allergen avoidance is often difficult, and the resulting efficiency is controversial.E3 Allergen-specific immunotherapy ha...

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Published in:Journal of allergy and clinical immunology 2011-04, Vol.127 (4), p.1069-1071.e7
Main Authors: Rondón, Carmen, MD, PhD, Blanca-López, Natalia, MD, PhD, Aranda, Ana, BS, Herrera, Rocío, BSN, Rodriguez-Bada, José Luis, BS, Canto, Gabriela, MD, PhD, Mayorga, Cristobalina, PhD, Torres, María José, MD, PhD, Campo, Paloma, MD, Blanca, Miguel, MD, PhD
Format: Article
Language:English
Subjects:
Administration, Sublingual
Allergies
Allergy and Immunology
Biological and medical sciences
Desensitization, Immunologic - methods
Disease
Drug therapy
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunopathology
Immunotherapy
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
Pilot Projects
Poaceae - immunology
Pollen
Pollen - immunology
Rhinitis, Allergic, Seasonal - immunology
Rhinitis, Allergic, Seasonal - prevention & control
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Currently, the majority of patients with LAR are treated with allergen avoidance measures and symptomatic medication with intranasal corticosteroids and oral antihistamines.E1E2 Allergen avoidance is often difficult, and the resulting efficiency is controversial.E3 Allergen-specific immunotherapy has proved an effective and safe treatment of allergic diseases that can reduce symptoms and medication requirements.E4-E6 Moreover, it is the only treatment that has the ability to modify the natural course of allergic rhinoconjunctivitis and provide efficacy in posttreatment years.E7 This study is the first to examine the immunologic and clinical response to specific SCIT in patients with LAR sensitized to grass pollen.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.12.013