Pituitary apoplexy: re-evaluation of risk factors for bleeding into pituitary adenomas and impact on outcome

ObjectiveTo assess frequency, symptoms and outcome of pituitary apoplexy (PA) among pituitary adenoma patients, to gain better insight into risk factors for bleeding into pituitary adenoma and to estimate the sequelae of PA by means of a matched control group.MethodBy reviewing charts of 574 patient...

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Bibliographic Details
Published in:European journal of endocrinology 2011-01, Vol.164 (1), p.37-43
Main Authors: Möller-Goede, Diane L, Brändle, Michael, Landau, Klara, Bernays, Rene L, Schmid, Christoph
Format: Article
Language:English
Subjects:
Adenoma - complications
Adenoma - diagnosis
Adenoma - pathology
Adult
Aged
Biological and medical sciences
Case-Control Studies
Clinical Study
Early Detection of Cancer
Endocrinopathies
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Incidental Findings
Male
Medical Records
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary Apoplexy - diagnosis
Pituitary Apoplexy - etiology
Pituitary Apoplexy - prevention & control
Pituitary Neoplasms - complications
Pituitary Neoplasms - diagnosis
Pituitary Neoplasms - pathology
Public health. Hygiene
Public health. Hygiene-occupational medicine
Retrospective Studies
Risk Assessment
Risk Factors
Sex Factors
Switzerland
Vertebrates: endocrinology
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Summary:ObjectiveTo assess frequency, symptoms and outcome of pituitary apoplexy (PA) among pituitary adenoma patients, to gain better insight into risk factors for bleeding into pituitary adenoma and to estimate the sequelae of PA by means of a matched control group.MethodBy reviewing charts of 574 patients with pituitary adenoma, we analysed incidence, symptoms and outcome of PA and potential risk factors for developing PA by means of a control group (patients with pituitary adenoma without PA).ResultsIn total, 42 suffered from PA, all had macroadenomas; 30/217 male (14%) and 12/179 female (7%) macroadenoma patients, 32/194 patients with clinically non-functioning (16.5%) and 10/202 with clinically active (5.0%) macroadenoma were affected. Antithrombotic therapy predisposed patients to PA (P=0.026), diabetes mellitus and hypertension did not (P=1.00). Patients with PA and pituitary adenoma patients without PA had similar frequencies of hypopituitarism (45 vs 48%, P>0.05) and visual field defects (38 vs 55%, P>0.05), but ophthalmoplegia was significantly more common (76 vs 5%, P
ISSN:0804-4643
1479-683X
DOI:10.1530/EJE-10-0651