The Impact of Early Viral Infections and Graft‐Versus‐Host Disease on Immune Reconstitution Following Paediatric Stem Cell Transplantation

Viral infections and graft‐versus‐host disease (GVHD) render an impact on both the clinical and immunological recovery following allogeneic hematopoietic stem cell transplantation (HSCT). We studied the recuperation of the immune defence after transplant in the paediatric setting and assessed the im...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2011-06, Vol.73 (6), p.586-593
Main Authors: Olkinuora, H., von Willebrand, E., Kantele, J. M., Vainio, O., Talvensaari, K., Saarinen‐Pihkala, U., Siitonen, S., Vettenranta, K.
Format: Article
Language:English
Subjects:
Adenoviridae - immunology
Adolescent
B-Lymphocytes - immunology
Cell Proliferation
Child
Child, Preschool
Cytomegalovirus - immunology
Flow Cytometry
Graft vs Host Disease - immunology
Hematopoietic Stem Cell Transplantation
Herpesvirus 4, Human - immunology
Humans
Infant
Prospective Studies
Statistics, Nonparametric
Survival Analysis
T-Lymphocytes - immunology
Thymus Gland - cytology
Thymus Gland - immunology
Virus Diseases - immunology
Young Adult
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Summary:Viral infections and graft‐versus‐host disease (GVHD) render an impact on both the clinical and immunological recovery following allogeneic hematopoietic stem cell transplantation (HSCT). We studied the recuperation of the immune defence after transplant in the paediatric setting and assessed the impact of early (
ISSN:0300-9475
1365-3083
DOI:10.1111/j.1365-3083.2011.02530.x