Serum uric acid level is associated with cardiac hypertrophy in renal transplant recipients

Caliskan Y, Gorgulu N, Yelken B, Akturk F, Yazici H, Turkmen A, Sever MS. Serum uric acid level is associated with cardiac hypertrophy in renal transplant recipients.
Clin Transplant 2011: 25: 368–374. © 2010 John Wiley & Sons A/S. :  Background:  Serum uric acid (UA) level as a significant and...

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Published in:Clinical transplantation 2011-05, Vol.25 (3), p.368-374
Main Authors: Caliskan, Yasar, Gorgulu, Numan, Yelken, Berna, Akturk, Faruk, Yazici, Halil, Turkmen, Aydin, Sever, Mehmet Sukru
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Cardiomegaly - blood
Cardiomegaly - diagnosis
Cardiomegaly - etiology
cardiovascular disease
Creatinine - blood
Echocardiography
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Hyperuricemia - blood
Hyperuricemia - diagnosis
Hyperuricemia - etiology
Kidney Failure, Chronic - surgery
Kidney Transplantation - adverse effects
left ventricle mass index
left ventricular hypertrophy
Male
Medical sciences
Metabolic diseases
Middle Aged
Other metabolic disorders
Prognosis
Purines and pyrimidines (gout, hyperuricemia...)
renal transplantation
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Survival Rate
Tissue, organ and graft immunology
uric acid
Uric Acid - blood
Young Adult
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Summary:Caliskan Y, Gorgulu N, Yelken B, Akturk F, Yazici H, Turkmen A, Sever MS. Serum uric acid level is associated with cardiac hypertrophy in renal transplant recipients.
Clin Transplant 2011: 25: 368–374. © 2010 John Wiley & Sons A/S. :  Background:  Serum uric acid (UA) level as a significant and independent risk factor for cardiovascular disease, and the link between this marker and left ventricular hypertrophy (LVH) in renal transplant recipients remains to be clarified. Methods:  A total of 141 renal transplant recipients (83 men), between ages of 18 and 69 (mean age 37 ± 11), were included in this single center study. In addition to demographic, clinical, and laboratory parameters, serum UA concentrations were evaluated. LVH was determined by two‐dimensional and M‐mode echocardiography. Results:  Serum UA levels were significantly higher (6.14 ± 1.15 mg/dL) in patients with LVH (n = 54) when compared to patients (n = 87) who did not have this abnormality (5.29 ± 1.43 mg/dL) (p = 0.006). Serum UA levels were significantly correlated with septal wall thickness, LV posterior wall thickness, LV mass index (LVMI), and pulmonary arterial pressure. Multiple linear regression analysis revealed that UA predicted LVMI (r2 = 0.150, β = 0.369, p = 0.001). However, serum creatinine (β = 0.060, p = 0.593) and age (β = 0.146, p = 0.175) were not predictors of LVMI. Conclusion:  High serum UA levels are associated with LVH in renal transplant recipients, which underlines the importance of treating hyperuricemia.
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2010.01244.x