Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

Graphical abstract. Highlights ► We synthetized four kynurenines structurally related to the neurohormone melatonin. ► These molecules were assayed in vivo in the mouse model of PD induced by MPTP. ► The four kynurenines reduced the inflammatory response in the nigrostriatal pathway induced by MPTP....

Full description

Saved in:
Bibliographic Details
Published in:Brain research bulletin 2011-05, Vol.85 (3), p.133-140
Main Authors: Acuña-Castroviejo, Dario, Tapias, Victor, López, Luis C, Doerrier, Carolina, Camacho, Encarnación, Carrión, María D, Mora, Francisco, Espinosa, Antonio, Escames, Germaine
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage
Animals
Corpus Striatum - metabolism
Corpus Striatum - ultrastructure
Cytosol - metabolism
Disease Models, Animal
Drug Administration Schedule
Inflammation
Kynurenine - chemistry
Kynurenine - therapeutic use
Lipid Peroxidation - drug effects
Male
Mice
Mice, Inbred C57BL
Mitochondria - drug effects
Mitochondria - metabolism
MPTP
MPTP Poisoning - pathology
MPTP Poisoning - prevention & control
NAD - metabolism
Neurology
Nitric Oxide Synthase Type I - metabolism
Nitric Oxide Synthase Type II - metabolism
Nitrites - metabolism
Oxidation-Reduction - drug effects
Oxidative stress
Substantia nigra
Substantia Nigra - drug effects
Substantia Nigra - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Graphical abstract. Highlights ► We synthetized four kynurenines structurally related to the neurohormone melatonin. ► These molecules were assayed in vivo in the mouse model of PD induced by MPTP. ► The four kynurenines reduced the inflammatory response in the nigrostriatal pathway induced by MPTP. ► These kynurenines also counteracted mitochondria failure and recovered mice from the neurotoxin effects. ► The compounds here tested may represent a new classes of neuroprotective drugs.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.03.008