Usefulness of Satisfactory Control of Low-Density Lipoprotein Cholesterol to Predict Left Ventricular Remodeling After a First ST-Elevation Myocardial Infarction Successfully Reperfused

Left ventricular (LV) remodeling represents an important determinant in the progression to heart failure in patients after myocardial infarction. The aim of the present study was to evaluate in patients with first ST-segment elevation acute myocardial infarction who were successfully and completely...

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Bibliographic Details
Published in:The American journal of cardiology 2011-06, Vol.107 (12), p.1772-1778
Main Authors: Buono, Francesco, MD, Spinelli, Letizia, MD, Giallauria, Francesco, MD, PhD, Assante di Panzillo, Emiliano, MD, Di Marino, Serena, MD, Ferrara, Fabio, MD, Vigorito, Carlo, MD, Trimarco, Bruno, MD, Morisco, Carmine, MD, PhD
Format: Article
Language:English
Subjects:
Angioplasty, Balloon, Coronary
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Cholesterol
Cholesterol, LDL - blood
Coronary heart disease
Echocardiography
Electrocardiography
Female
Heart
Heart attacks
Heart failure
Humans
Low density lipoprotein
Male
Medical sciences
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Myocardial Reperfusion
Myocarditis. Cardiomyopathies
Stroke Volume
Thrombolytic Therapy
Veins & arteries
Ventricular Remodeling
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Summary:Left ventricular (LV) remodeling represents an important determinant in the progression to heart failure in patients after myocardial infarction. The aim of the present study was to evaluate in patients with first ST-segment elevation acute myocardial infarction who were successfully and completely reperfused whether the control of cholesterol is predictive of LV remodeling. A total of 109 patients referred to a coronary care unit for first ST-segment elevation myocardial infarction were analyzed. According to the change in indexed LV end-diastolic volume detected at follow-up visits, patients were divided into nonremodeling (n = 79) and remodeling (n = 30) groups. At coronary care unit admission, the prevalence of cardiovascular risk factors was similar in the 2 groups. Low-density lipoprotein (LDL) cholesterol values were used as criteria for cholesterol control. At follow-up visits, the prevalence of patients with target levels of plasma LDL cholesterol was lower in the remodeling compared to the nonremodeling group (67% and 91%, respectively, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2011.01.066