Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a multicomponent disease. Autoimmunity can contribute to the pathogenesis of COPD. This study investigates the prevalence of circulating antinuclear antibodies (ANA) and anti-tissue (AT) antibodies, two common markers of autoimmunity, in COPD and their...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2011-04, Vol.183 (8), p.1025-1031
Main Authors: Núñez, Belén, Sauleda, Jaume, Antó, Josep Maria, Julià, Maria Rosa, Orozco, Mauricio, Monsó, Eduard, Noguera, Aina, Gómez, Federico P, Garcia-Aymerich, Judith, Agustí, Alvar
Format: Article
Language:English
Subjects:
Aged
Antibodies
Antibodies, Antinuclear - immunology
Autoantibodies - immunology
Blood & organ donations
Body mass index
C-Reactive Protein - analysis
Case-Control Studies
Chronic obstructive pulmonary disease
Cross-Sectional Studies
Dyspnea
Emphysema
Female
Fluorescent Antibody Technique
Forced Expiratory Volume
Humans
Lung - immunology
Lung - physiopathology
Male
Middle Aged
Nephelometry and Turbidimetry
Nutritional status
Pathogenesis
Patients
Proteins
Pulmonary Disease, Chronic Obstructive - immunology
Pulmonary Disease, Chronic Obstructive - physiopathology
Questionnaires
Smoking
Spirometry
Tobacco
Values
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Summary:Chronic obstructive pulmonary disease (COPD) is a multicomponent disease. Autoimmunity can contribute to the pathogenesis of COPD. This study investigates the prevalence of circulating antinuclear antibodies (ANA) and anti-tissue (AT) antibodies, two common markers of autoimmunity, in COPD and their relationship with several components of the disease. We determined lung function, the serum titers of ANA and AT by immunofluorescence, and the serum levels of C-reactive protein (CRP) by high sensitivity nephelometry in 328 patients with clinically stable COPD and in 67 healthy controls recruited in the PAC-COPD study. Multiple linear and logistic regression analysis was used to analyze results. The prevalence of abnormal ANA and AT titers was 34% and 26% in patients and 3% and 6% in controls, respectively. Levels of AT greater than or equal to 1:320 were seen in 21% of patients with COPD and were independently associated with the severity of airflow limitation and gas transfer impairment (P < 0.05). Neither ANA or AT titers was related to body mass index, current smoking status, use of inhaled steroids, the Charlson index, or serum C-reactive protein values. Between a quarter and a third of patients with clinically stable COPD present abnormal titers of circulating ANA and AT. The observed relationship between AT and lung function supports a role for autoimmunity in the pathogenesis of COPD.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201001-0029oc